ArticleOncology letters2012
Overexpression of DJ-1 and HSP90α, and loss of PTEN associated with invasive urothelial carcinoma of urinary bladder: Possible prognostic markers.
Article in Oncology letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Evaluation of expression profiles of APOA4, CEACAM1, CD147, DJ-1/PARK7, Gamma-synuclein, S100A1, and Stathmin-1 in urothelial carcinomas using immunohistochemical assays.Frontiers in oncology · 2025Article
- Research and progress of microRNA-136 in metastatic tumors.Frontiers in oncology · 2025Review
- Integrated multiomics analysis of chromosome 19 miRNA cluster in bladder cancer.Functional & integrative genomics · 2023Article
- PARK7 deficiency inhibits fatty acid β-oxidation via PTEN to delay liver regeneration after hepatectomy.Clinical and translational medicine · 2022Article
- Article
- Review
- Upregulation of DJ-1 expression in melanoma regulates PTEN/AKT pathway for cell survival and migration.Archives of dermatological research · 2021Article
- Maspin is a PTEN-Upregulated and p53-Upregulated Tumor Suppressor Gene and Acts as an HDAC1 Inhibitor in Human Bladder Cancer.Cancers · 2019Article
- Transgelin, a p53 and PTEN-Upregulated Gene, Inhibits the Cell Proliferation and Invasion of Human Bladder Carcinoma Cells in Vitro and in Vivo.International journal of molecular sciences · 2019Article
- Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.Journal of bioenergetics and biomembranes · 2019Review
- Precise definition of PTEN C-terminal epitopes and its implications in clinical oncology.NPJ precision oncology · 2019Article
- Systematic verification of bladder cancer-associated tissue protein biomarker candidates in clinical urine specimens.Oncotarget · 2018Article
- Microrna-136 promotes proliferation and invasion ingastric cancer cells through Pten/Akt/P-Akt signaling pathway.Oncology letters · 2018Article
- Cyclooxygenase inhibitors potentiate receptor tyrosine kinase therapies in bladder cancer cells in vitro.Drug design, development and therapy · 2018Article
- BTG2 is a tumor suppressor gene upregulated by p53 and PTEN in human bladder carcinoma cells.Cancer medicine · 2018Article
- Phosphorylated mTOR Expression Profiles in Human Normal and Carcinoma Tissues.Disease markers · 2017Article
- DJ-1 Expression in Cervical Carcinoma and its Effects on Cell Viability and Apoptosis.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- A Systematic Review of the Diagnostic and Prognostic Value of Urinary Protein Biomarkers in Urothelial Bladder Cancer.Bladder cancer (Amsterdam, Netherlands) · 2016Article
- Oxidant-induced Interprotein Disulfide Formation in Cardiac Protein DJ-1 Occurs via an Interaction with Peroxiredoxin 2.The Journal of biological chemistry · 2016Article
- Highly sensitive and specific novel biomarkers for the diagnosis of transitional bladder carcinoma.Oncotarget · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DJ-1 and HSP90α play a significant role in the progression of various types of cancer and are known to be associated with phosphatase and tensin homolog deleted on chromosome 10 (PTEN), PI3K-p110α and pAkt, the signaling molecule proteins from the phosphatidylinositol 3-kinase (PI3K) pathway. However, the expression of these proteins and their clinical significance are not well characterized in urothelial carcinoma (UC). Immunohistochemical analysis of DJ-1, HSP90α, PTEN, pAkt and PI3K-p110α expression was performed on tumor samples from 102 patients with UC to assess the relationship between the expression of each protein and the pathological parameters. The expression of DJ-1 and HSP90α was positively correlated with the pathological stage of UC, whereas PTEN expression negatively correlated with, not only the pathological stage, but also the growth pattern and histological grade of UC. Although PI3K-p110α expression was significantly correlated with DJ-1 as well as PTEN expression in UC, PI3K-p110α expression itself failed to reveal any significant correlation with the clinicopathological parameters. In conclusion, the overexpression of DJ-1 and HSP90α, and a loss of PTEN are associated with invasive UC, and PI3K-p110α expression is correlated with DJ-1 and PTEN expression in UC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.