ArticleMolecular biology of the cell2012
Polarization of actin cytoskeleton is reduced in dendritic protrusions during early spine development in hippocampal neuron.
Article in Molecular biology of the cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in neurons.The Journal of cell biology · 2023Article
- Rac-maninoff and Rho-vel: The symphony of Rho-GTPase signaling at excitatory synapses.Small GTPases · 2022Article
- Simultaneous analyses of clutch coupling and actin polymerization in dendritic spines of rodent hippocampal neurons during chemical LTP.STAR protocols · 2021Article
- Following the footprints of variability during filopodial growth.European biophysics journal : EBJ · 2020Article
- Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins.Scientific reports · 2019Article
- Using Single-Protein Tracking to Study Cell Migration.Methods in molecular biology (Clifton, N.J.) · 2018Article
- The Emerging Role of Mechanics in Synapse Formation and Plasticity.Frontiers in cellular neuroscience · 2018Review
- Optogenetic activation of EphB2 receptor in dendrites induced actin polymerization by activating Arg kinase.Biology open · 2017Article
- A minimal actomyosin-based model predicts the dynamics of filopodia on neuronal dendrites.Molecular biology of the cell · 2017Article
- Ras and Rab interactor 1 controls neuronal plasticity by coordinating dendritic filopodial motility and AMPA receptor turnover.Molecular biology of the cell · 2017Article
- The Nanoworld of the Tripartite Synapse: Insights from Super-Resolution Microscopy.Frontiers in cellular neuroscience · 2017Article
- Organization and dynamics of the actin cytoskeleton during dendritic spine morphological remodeling.Cellular and molecular life sciences : CMLS · 2016Review
- Focusing super resolution on the cytoskeleton.F1000Research · 2016Review
- Mechanical coupling between transsynaptic N-cadherin adhesions and actin flow stabilizes dendritic spines.Molecular biology of the cell · 2015Article
- The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation.Molecular neurodegeneration · 2014Article
- Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion.The EMBO journal · 2014Article
- Damage of hippocampal neurons in rats with chronic alcoholism.Neural regeneration research · 2014Article
- Article
- Actin dynamics affect mitochondrial quality control and aging in budding yeast.Current biology : CB · 2013Article
- Measuring actin flow in 3D cell protrusions.Biophysical journal · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Dendritic spines are small protrusions that receive synaptic signals in neuronal networks. The actin cytoskeleton plays a key role in regulating spine morphogenesis, as well as in the function of synapses. Here we report the first quantitative measurement of F-actin retrograde flow rate in dendritic filopodia, the precursor of dendritic spines, and in newly formed spines, using a technique based on photoactivation localization microscopy. We found a fast F-actin retrograde flow in the dendritic filopodia but not in the spine necks. The quantification of F-actin flow rates, combined with fluorescence recovery after photobleaching measurements, allowed for a full quantification of spatially resolved kinetic rates of actin turnover, which was not previously feasible. Furthermore we provide evidences that myosin II regulates the actin flow in dendritic filopodia and translocates from the base to the tip of the protrusion upon spine formation. Rac1 inhibition led to mislocalization of myosin II, as well as to disruption of the F-actin flow. These results provide advances in the quantitative understanding of F-actin remodeling during spine formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.