Evidence map›Paper›PMID 22740408›Full record

ArticleJournal of virology2012

Identification of MW polyomavirus, a novel polyomavirus in human stool.

Erica A Siebrasse, Alejandro Reyes, Efrem S Lim, Guoyan Zhao, Rajhab S Mkakosya, Mark J Manary, Jeffrey I Gordon, David Wang

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 196 citations in OpenAlex.

  1. Trial
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  5. Shotgun metagenomics on indoor air for surveillance of respiratory, enteric, and skin viruses in a Belgian daycare setting, January to December 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  6. Review
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  9. Article
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  13. Gut virome in early life: origins and implications.Current opinion in virology · 2022
    Review
  14. [Human polyomavirus-associated skin diseases].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2022
    Review
  15. Article
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  20. Biology of Polyomavirus miRNA.Frontiers in microbiology · 2021
    Review

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Erica A SiebrasseDepartment of Molecular Microbiology and Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Alejandro Reyes
Efrem S Lim
Guoyan Zhao
Rajhab S Mkakosya
Mark J Manary
Jeffrey I Gordon
David Wang
Washington University in St. Louis · USUniversity of Malawi · MW

Funding

Virology and Smallpox VaccinationsU54AI057160 · NIAID · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 2003 to 2013
$80.9M
NIAID NIH HHS U54 AI057160
6 · The paper itself

Abstract

We have discovered a novel polyomavirus present in multiple human stool samples. The virus was initially identified by shotgun pyrosequencing of DNA purified from virus-like particles isolated from a stool sample collected from a healthy child from Malawi. We subsequently sequenced the virus' 4,927-bp genome, which has been provisionally named MW polyomavirus (MWPyV). The virus has genomic features characteristic of the family Polyomaviridae but is highly divergent from other members of this family. It is predicted to encode the large T antigen and small T antigen early proteins and the VP1, VP2, and VP3 structural proteins. A real-time PCR assay was designed and used to screen 514 stool samples from children with diarrhea in St. Louis, MO; 12 specimens were positive for MWPyV. Comparison of the whole-genome sequences of the index Malawi case and one St. Louis case demonstrated that the two strains of MWPyV varied by 5.3% at the nucleotide level. The number of polyomaviruses found in the human body continues to grow, raising the question of how many more species have yet to be identified and what roles they play in humans with and without manifest disease.

Indexed as

AdolescentAntigens, Viral, TumorChildChild, PreschoolFecesFemaleGenetic VariationGenome, ViralHumansInfantInfant, NewbornMalawiMolecular Sequence DataPhylogenyPolyomavirusSequence Analysis, DNAAntigens, Viral, Tumor

Identifiers

PMID22740408
PMCPMC3457274
OpenAlexW2163631211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.