Evidence map›Paper›PMID 22740289›Full record

ArticleInternational journal of geriatric psychiatry2013

Longitudinal studies of cerebral glucose metabolism in late-life depression and normal aging.

Christopher M Marano, Clifford I Workman, Elisse Kramer, Carol R Hermann, Yilong Ma, Vijay Dhawan, Thomas Chaly, David Eidelberg, Gwenn S Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of geriatric psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Depressive symptoms accelerate cognitive decline in amyloid-positive MCI patients.European journal of nuclear medicine and molecular imaging · 2015
    Observational
  6. Review
  7. Bioenergetic medicine.British journal of pharmacology · 2014
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Christopher M MaranoDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Clifford I Workman
Elisse Kramer
Carol R Hermann
Yilong Ma
Vijay Dhawan
Thomas Chaly
David Eidelberg
Gwenn S Smith
Johns Hopkins Medicine · USFeinstein Institute for Medical Research · USNorthwell Health · USZucker Hillside Hospital · US

Funding

WHITE MATTER STRUCTURAL DEFICITS IN HIGH FUNCTIONING CHILDREN WITH AUTISM SPEM01RR018535 · NCRR · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI MATTIS, PAUL · 2003 to 2010
$19.5M
Geriatric Depression: PET Studies of Pathophysiology and Treatment ResponseR01MH086881 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SMITH, GWENN S · 2010 to 2013
$2.7M
Serotonin Modulation in Geriatric DepressionR01MH064823 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SMITH, GWENN S. · 2003 to 2006
$1.9M
MONOAMINERGIC FUNCTION IN GERIATRIC NEUROPSYCHIATRYK02MH001621 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SMITH, GWENN S · 1998 to 2008
$884k
PET STUDIES OF CHOLINERGIC MODULATION IN ALZHEIMERSR01MH057078 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SMITH, GWENN S · 1997 to 2000
$293k
PET STUDIES OF NEUROTRANSMITTER INTERACTIONS IN HUMANSR01MH049936 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SMITH, GWENN S · 1993 to 1999
–
NCRR NIH HHS M01 RR018535NIMH NIH HHS K02 MH001621NIMH NIH HHS MH 01621NIMH NIH HHS MH 49936NIMH NIH HHS MH 57078NIMH NIH HHS MH 64823NIMH NIH HHS MH M01 RR 018535NIMH NIH HHS R01 MH049936NIMH NIH HHS R01 MH057078NIMH NIH HHS R01 MH064823NIMH NIH HHS R01 MH086881NIMH NIH HHS R01 MH 86881
6 · The paper itself

Abstract

objectiveLate-life depression (LLD) has a substantial public health impact and is both a risk factor for and a prodrome of dementia. Positron emission tomography (PET) studies of cerebral glucose metabolism have demonstrated sensitivity in evaluating neural circuitry involved in depression, aging, incipient cognitive decline, and dementia. The present study evaluated the long term effects of a course of antidepressant treatment on glucose metabolism in LLD patients.

methodsNine LLD patients and seven non-depressed control subjects underwent clinical and cognitive evaluations as well as brain magnetic resonance imaging and PET studies of cerebral glucose metabolism at baseline, after 8 weeks of treatment with citalopram for a major depressive episode (patients only), and at an approximately 2-year follow-up.

resultsThe majority of LLD patients were remitted at follow-up (7/9). Neither patients nor controls showed significant cognitive decline. The patients showed greater increases in glucose metabolism than the controls in regions associated with mood symptoms (anterior cingulate and insula). Both groups showed decreases in metabolism in posterior association cortices implicated in dementia.

conclusionsLongitudinal changes in cerebral glucose metabolism are observed in controls and in LLD patients without significant cognitive decline that are more extensive than the decreases in brain volume. Longer duration follow-up studies and the integration of other molecular imaging methods will have implications for understanding the clinical and neurobiological significance of these metabolic changes.

Indexed as

AgedAged, 80 and overAge of OnsetAgingCerebellumCitalopramCognition DisordersFemaleGlucoseHumansLongitudinal StudiesMajor Depressive DisorderMalePositron-Emission TomographyCitalopramGlucose

Identifiers

PMID22740289
PMCPMC3974580
OpenAlexW1522731215

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.