ArticlePharmaceutical research2012
Drug-loaded polymeric composite skin graft for infection-free wound healing: fabrication, characterization, cell proliferation, migration, and antimicrobial activity.
Article in Pharmaceutical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 14 citations in OpenAlex.
- Antibiotics againstPharmaceutics · 2024Article
- Assessing the Efficacy of PLGA-Loaded Antimicrobial Peptide OH-CATH30 Microspheres for the Treatment of Bacterial Keratitis: A Promising Approach.Biomolecules · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA new, injectable, drug-loaded composite graft was developed to enable infection free wound healing.
methodsThe graft was fabricated using gentamicin and biomimetic microparticulate scaffolds in gelatin gel and characterized for biologically relevant properties like fluid uptake, evaporative water loss (EWL), water vapor transmission rate (WVTR), Young's modulus and degradation. It was evaluated for drug release, cytocompatibility and antimicrobial efficacy against Staphylococcus aureus and Pseudomonas aeruginosa.
resultsGraft exhibited fluid uptake of 13.79%, EWL of 60-70% in 10 h, WVTR of 5480.31 g/m(2)/d, and Young's modulus as 2.1-10.8 kPa. It exhibited 99.36% degree of crosslinking and a dual degradation behavior wherein, the carrier gel, gelatin, degraded rapidly leaving the microparticulate scaffolds intact. Drug release studies showed a sustained release of gentamicin for 13 days sufficient to inhibit the infection at the wound site. Cytocompatibility assessment of the graft revealed that graft supported cell adhesion, proliferation and migration. The antibacterial efficacy of the graft was assessed using Kirby-Bauer method and time kill assay, wherein results indicated a quick, effective (≥ 5-log reduction in CFU/ml) and long lasting antimicrobial effect.
conclusionsThese results as a whole indicate that the graft represents an effective alternative for infection-free healing of full thickness wounds.
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Registered trials
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