Evidence map›Paper›PMID 22739962›Full record

ReviewThe Journal of membrane biology2012

Posttranslational modifications in connexins and pannexins.

Scott R Johnstone, Marie Billaud, Alexander W Lohman, Evan P Taddeo, Brant E Isakson

Abstract readReview
In one paragraph

Review in The Journal of membrane biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Review
  2. Deceiving the gatekeepers: virus modulation of gap junctions.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Molecular Dynamics Simulation of Permeation Through Connexin Channels.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Mechanisms of Connexin Regulating Peptides.International journal of molecular sciences · 2021
    Review
  18. Review
  19. Mechanisms Underlying Connexin Hemichannel Activation in Disease.International journal of molecular sciences · 2021
    Review
  20. Review

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Scott R JohnstoneRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Marie Billaud
Alexander W Lohman
Evan P Taddeo
Brant E Isakson

Funding

Mechanisms of Heterocellular Signaling at the Myoenothelial JunctionR01HL088554 · NHLBI · UNIVERSITY OF VIRGINIA · PI ISAKSON, BRANT E, WEISS, MITCHELL J · 2008 to 2017
$3.8M
Mechanism of PAI-1 Polarization to Myoendothelial JunctionsR21HL107963 · NHLBI · UNIVERSITY OF VIRGINIA · PI ISAKSON, BRANT E · 2012 to 2013
$414k
NHLBI NIH HHS HL088554NHLBI NIH HHS HL107963NHLBI NIH HHS R01 HL088554NHLBI NIH HHS R21 HL107963
6 · The paper itself

Abstract

Posttranslational modification is a common cellular process that is used by cells to ensure a particular protein function. This can happen in a variety of ways, e.g., from the addition of phosphates or sugar residues to a particular amino acid, ensuring proper protein life cycle and function. In this review, we assess the evidence for ubiquitination, glycosylation, phosphorylation, S-nitrosylation as well as other modifications in connexins and pannexin proteins. Based on the literature, we find that posttranslational modifications are an important component of connexin and pannexin regulation.

Indexed as

AnimalsConnexinsGlycosylationHumansPhosphorylationProtein Processing, Post-TranslationalUbiquitinationConnexins

Identifiers

PMID22739962
PMCPMC3954810

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.