ArticleNaunyn-Schmiedeberg's archives of pharmacology2012
Gastroprotective activity of carvacrol on experimentally induced gastric lesions in rodents.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Phytotherapeutics self-microemulsifying systems in pellet dosage form for enhanced intestinal drug delivery: formulation, stability, andDrug delivery · 2026Article
- Role of Carvacrol in Oral Health: An Overview.Current pharmaceutical design · 2026Review
- Carvacrol in asthma management: a comprehensive review of its therapeutic potential and mechanisms of action.Pharmacological reports : PR · 2025Review
- Peripheral Antinociception Induced by Carvacrol in the Formalin Test Involves the Opioid Receptor-NO-cGMP-KMetabolites · 2025Article
- Investigating the pharmacological potential of phytol on experimental models of gastric ulcer in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- The effects and mechanisms of natural products onFrontiers in cellular and infection microbiology · 2024Review
- Antioxidant Mechanisms Underlying the Gastroprotective Effect of Menthofuran on Experimentally Induced Gastric Lesions in Rodents.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Therapeutic application of carvacrol: A comprehensive review.Food science & nutrition · 2022Review
- In Vitro Screening of Non-Antibiotic Components to Mitigate Intestinal Lesions Caused byAnimals : an open access journal from MDPI · 2022Article
- Clinical and Metabolomic Effects of Lactiplantibacillus plantarum and Pediococcus acidilactici in Fructose Intolerant PatientsNutrients · 2022Article
- Gastroprotective Effect of MicroencapsulatedMolecules (Basel, Switzerland) · 2022Article
- (-)-Carveol Prevents Gastric Ulcers via Cytoprotective, Antioxidant, Antisecretory and Immunoregulatory Mechanisms in Animal Models.Frontiers in pharmacology · 2021Article
- Systematic Analysis of Monoterpenes: Advances and Challenges in the Treatment of Peptic Ulcer Diseases.Biomolecules · 2020Review
- Gastroprotective effect of cilostazol against ethanol- and pylorus ligation-induced gastric lesions in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2019Article
- Protective activity of geraniol against acetic acid andJournal of traditional and complementary medicine · 2019Article
- Trachyspermum ammi (L.) Sprague, superb essential oil and its major components on peptic ulcers: in vivo combined in silico studies.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2019Article
- Effects of essential oil of Satureja khuzestanica on the oxidative stress in experimental hyperthyroid male rat.Veterinary research forum : an international quarterly journal · 2015Article
- Anti-ulcer activity of essential oil constituents.Molecules (Basel, Switzerland) · 2014Review
- Geraniol-a flavoring agent with multifunctional effects in protecting the gastric and duodenal mucosa.Naunyn-Schmiedeberg's archives of pharmacology · 2014Article
- Evidence of K+ channel function in epithelial cell migration, proliferation, and repair.American journal of physiology. Cell physiology · 2014Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to investigate the gastroprotective activity of carvacrol, a monoterpene present in essential oils from several species of medicinal and aromatic plants, by using different models of acute gastric lesions in rodents and also evaluate possible mechanisms involved in this action. For this study, absolute ethanol-, acidified ethanol-, ischemia and reperfusion-, and nonsteroidal anti-inflammatory drug-induced models of gastric lesions in mice and rats were used. The roles of nonprotein sulfhydryl groups, catalase, nitric oxide (NO), ATP-sensitive potassium channels (K(ATP) channels), and prostaglandins in carvacrol-induced gastroprotective effect were investigated. In addition, the effects of carvacrol on gastric secretion and mucus in pylorus-ligated rats were also determined. The results of the present study demonstrated that carvacrol promoted a marked gastroprotection in all models investigated, possibly mediated by endogenous prostaglandins, increase of mucus production, K(ATP) channels opening, NO synthase activation, and antioxidant properties. These findings markedly substantiate further studies to investigate the therapeutic potential of carvacrol as an effective gastroprotective agent and its safety profile in medicinal use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.