ArticleThe Pediatric infectious disease journal2012
Detecting respiratory viruses in asymptomatic children.
Article in The Pediatric infectious disease journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Literature Review of Respiratory Syncytial Virus Laboratory Testing Practices and Incidence in United States Infants and Children <5 Years of Age.The Journal of infectious diseases · 2022Pooled it
- PreDicta chip-based high resolution diagnosis of rhinovirus-induced wheeze.Nature communications · 2018Trial
- The respiratory health of urban indigenous children aged less than 5 years: study protocol for a prospective cohort study.BMC pediatrics · 2015Trial
- Article
- Rapid diagnosis of acute pediatric respiratory infections with Point-of-Care and multiplex molecular testing.Infection · 2025Review
- Respiratory virus infections in symptomatic and asymptomatic children upon hospital admission: new insights.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Impact of asymptomatic detection of non-SARS-CoV-2 respiratory viruses on pediatric cardiac surgical outcomes.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Article
- Article
- Comparison of Severe Viral Pneumonia Caused by SARS-CoV-2 and Other Respiratory Viruses Among Malaysian Children During the COVID-19 Pandemic.Frontiers in pediatrics · 2022Article
- Detection of Respiratory Pathogens Does Not Predict Risks After Outpatient Adenotonsillectomy.The Laryngoscope · 2021Article
- Article
- Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium.Nature communications · 2020Article
- Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium.bioRxiv : the preprint server for biology · 2020Article
- Epidemiology of human respiratory viruses in children with acute respiratory tract infection in a 3-year hospital-based survey in Northern Italy.Diagnostic microbiology and infectious disease · 2019Article
- Respiratory virus associated with surgery in children patients.Respiratory research · 2019Observational
- Respiratory Testing and Hospital Outcomes in Asymptomatic Infants Undergoing Heart Surgery.Pediatric cardiology · 2019Observational
- Impact of community respiratory viral infections in urban children with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Article
- Target-independent high-throughput sequencing methods provide evidence that already known human viral pathogens play a main role in respiratory infections with unexplained etiology.Emerging microbes & infections · 2019Article
- PCR Detection of Respiratory Pathogens in Asymptomatic and Symptomatic Adults.Journal of clinical microbiology · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundViral respiratory infections are among the most common reasons for hospitalization of children in the United States. Our objective was to compare molecular and conventional methods in a cohort of hospitalized children with and without symptoms of respiratory viral illness (RVI).
methodsWe conducted a retrospective cohort study of infants and toddlers hospitalized between December 2007 and March 2008 at Johns Hopkins Hospital. Five hundred sixty-nine of 641 patient visits (89%) were tested on admission. Conventional tests (immunochromatography, direct fluorescent antibody, shell vial and tube culture) were performed on all patients and nucleic acid tests (NATs) were performed on available samples (n = 306). Viruses were grouped into those routinely (group 1) and those not routinely (group 2) detected by conventional methods.
resultsIn children with RVI symptoms (n = 148), NATs identified a virus in 83% of specimens compared with 49% by conventional methods (P < 0.001), but detected a similar percentage of specimens with group 1 viruses (48.6% and 55.4%; P = 0.13) compared with conventional tests. In children without RVI symptoms (n = 158), NATs identified a virus in 41.7% of specimens compared with 4.4% by conventional tests (P < 0.001) and identified more group 1 viruses (9.5% and 4.4%; P = 0.03) compared with conventional tests. Group 2 viruses were identified by NATs in a similar percentage of symptomatic and asymptomatic patients (25% and 32.3%; P = 0.20).
conclusionsMolecular assays may have several advantages over conventional methods for detecting respiratory viruses, including improved sensitivity and rapid detection, but given the high prevalence of positive results in children without RVI symptoms, results should be interpreted cautiously.
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