Trial reportThe Journal of pediatrics2012
Low oxygen saturation target range is associated with increased incidence of intermittent hypoxemia.
Trial report in The Journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00233324 (Surfactant Positive Airway Pressure and Pulse Oximetry Trial), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) in Extremely Low Birth Weight Infants
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Usual Care and Informed Consent in Clinical Trials of Oxygen Management in Extremely Premature Infants.PloS one · 2016Pooled it
- Oxygen saturation target range for extremely preterm infants: a systematic review and meta-analysis.JAMA pediatrics · 2015Pooled it
- Prone Positioning Was Associated With Less Hypoxemic Events and Improved Feeding Tolerance in Preterm Infants.Acta paediatrica (Oslo, Norway : 1992) · 2025Trial
- Control of breathing in preterm infants on incubator oxygen or nasal cannula oxygen.Pediatric research · 2025Trial
- Extended CPAP or low-flow nasal cannula for intermittent hypoxaemia in preterm infants: a 24-hour randomised clinical trial.Archives of disease in childhood. Fetal and neonatal edition · 2024Trial
- Non-invasive duo positive airway pressure ventilation versus nasal continuous positive airway pressure in preterm infants with respiratory distress syndrome: a randomized controlled trial.BMC pediatrics · 2021Trial
- Environmental or Nasal Cannula Supplemental Oxygen for Preterm Infants: A Randomized Cross-Over Trial.The Journal of pediatrics · 2018Trial
- Patterns of Oxygenation, Mortality, and Growth Status in the Surfactant Positive Pressure and Oxygen Trial Cohort.The Journal of pediatrics · 2017Trial
- Growth Outcomes of Preterm Infants Exposed to Different Oxygen Saturation Target Ranges from Birth.The Journal of pediatrics · 2016Trial
- Short-Term Physiological Effects of Red Blood Cell Transfusion in Very Low Birth Weight Infants: A Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
- Beyond oxygen targets: the DOSE framework as a conceptual model for dynamic oxygen stewardship in retinopathy of prematurity.Frontiers in pediatrics · 2026Article
- Intermittent Hypoxemia and Neurodevelopmental Impairment at 12 and 24 Months in Preterm Infants.Neonatology · 2025Article
- The effectiveness of automated adjustment of inspired oxygen in preterm infants receiving respiratory support compared with manual: A systematic review and meta-analysis.Pediatric discovery · 2024Review
- Apnea of Prematurity and Oxidative Stress: Potential Implications.Antioxidants (Basel, Switzerland) · 2024Review
- Maturation of cardioventilatory physiological trajectories in extremely preterm infants.Pediatric research · 2024Article
- Lower Versus Higher Oxygenation Targets for Critically Ill Patients: A Systematic Review.Cureus · 2023Review
- Neonatal intermittent hypoxia persistently impairs lung vascular development and induces long-term lung mitochondrial DNA damage.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Pulmonary Resilience: Moderating the Association between Oxygen Exposure and Pulmonary Outcomes in Extremely Preterm Newborns.Neonatology · 2022Review
- Intermittent Hypoxemia and Bronchopulmonary Dysplasia: Manifestations of Immature Respiratory Control and the Preterm Lung.American journal of respiratory and critical care medicine · 2021Article
- The twofold NICU challenge: avoiding hypoxia and hyperoxia.Pediatric research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveTo test the hypothesis that preterm infants randomized to a low vs high O(2) saturation target range have a higher incidence of intermittent hypoxemia. STUDY
designA subcohort of 115 preterm infants with high resolution pulse oximetry enrolled in the Surfactant, Positive Pressure, and Oxygenation Randomized Trial were randomized to low (85%-89%) or high (91%-95%) O(2) saturation target ranges. Oxygen saturation was monitored until 36 weeks postmenstrual age or until the infant was breathing room air without respiratory support for ≥72 hours.
resultsThe low target O(2) saturation group had a higher rate of intermittent hypoxemia (≤80% for ≥10 seconds and ≤3 minutes) prior to 12 days and beyond 57 days of life (P < .05). The duration shortened (P < .0001) and the severity increased (P < .0001) with increasing postnatal age with no differences between target saturation groups. The higher rate of intermittent hypoxemia events in the low target group was associated with a time interval between events of <1 minute.
conclusionA low O(2) saturation target was associated with an increased rate of intermittent hypoxemia events that was dependent on postnatal age. The duration and severity of events was comparable between target groups. Further investigation is needed to assess the role of intermittent hypoxemia and their timing on neonatal morbidity.
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Registered trials
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