Evidence map›Paper›PMID 22737634›Full record

ArticleAmerican journal of neurodegenerative disease2012

Select non-coding RNA in blood components provide novel clinically accessible biological surrogates for improved identification of traumatic brain injury in OEF/OIF Veterans.

Giulio M Pasinetti, Lap Ho, Christopher Dooley, Bhavna Abbi, Gudrun Lange

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of neurodegenerative disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. A Review of MicroRNA Biomarkers in Traumatic Brain Injury.Journal of experimental neuroscience · 2019
    Review
  11. Article
  12. Article
  13. Biochemical changes in the injured brain.World journal of biological chemistry · 2017
    Article
  14. Article
  15. Review
  16. The epigenetics of aging and neurodegeneration.Progress in neurobiology · 2015
    Review
  17. Article
  18. Epilepsy related to traumatic brain injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Giulio M PasinettiDepartment of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Lap Ho
Christopher Dooley
Bhavna Abbi
Gudrun Lange
Icahn School of Medicine at Mount Sinai · US

Funding

Anti-hypertensive drugs that prevent Alzheimer's disease beta-amyloid pathology aU01AG029310 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PASINETTI, GIULIO MARIA · 2007 to 2010
$909k
NIA NIH HHS U01 AG029310
6 · The paper itself

Abstract

This study was designed to identify clinically accessible molecular biomarkers of mild traumatic brain injury (mTBI) that could be used to help identify returning Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF) Veterans who are suffering from the effects of mTBI. While analyzing the expression profile of small non-coding RNAs in peripheral blood mononuclear cells (PBMCs) from an OEF/OIF veteran study cohort using a high throughput array chip platform, we identified 18 candidate small non-coding RNA biomarkers that are differentially regulated in PBMCs of mTBI compared to non-TBI control cases. Independent quantitative real-time polymerase chain reaction assays confirmed that 13 of these candidate small RNA biomarker species are, indeed, significantly down-regulated in PBMCs of mTBI compared to non-TBI control veteran cases. Based on unsupervised clustering analysis, we identified a 3-biomarker panel which was most able to distinguish mTBI from non-TBI control veteran cases with high accuracy, selectivity and specificity. The majority of mTBI cases in our biomarker study were co-morbid with Post-Traumatic Stress Disorder (PTSD), and thus our non-TBI control cases were selected to match PTSD diagnoses. Therefore, our identified panel of 3 small RNA biomarkers likely represents a biological index selective for mTBI. Outcomes from our studies suggest that additional applications of the clinically accessible small non-coding RNA biomarkers to current diagnostic criteria may lead to improved mTBI detection and more sensitive outcome measures for clinical trials. Future studies exploring the physiological relevance of mTBI biomarkers will also provide a better understanding of the biological mechanisms underlying mTBI and insights into novel therapeutic targets for mTBI.

Indexed as

biomarkersmicroRNA (miRNA)Mild traumatic brain injury (mTBI)post-traumatic stress disorder (PTSD)

Identifiers

PMID22737634
PMCPMC3560446
OpenAlexW2128282474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.