ArticleWorld journal of gastrointestinal pathophysiology2012
Gender-associated differences in urea breath test for Helicobacter pylori infection referrals and results among dyspeptic patients.
Article in World journal of gastrointestinal pathophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Proportion and Characteristics of Helicobacter Pylori -Negative Gastric Mucosa-Associated Lymphoid Tissue Lymphoma: A Systematic Review and Meta-Analysis.Clinical and translational gastroenterology · 2025Pooled it
- Association between Helicobacter pylori infection and thyroid dysfunction in adults visiting a tertiary care hospital in Karachi, Pakistan: a cross-sectional study.BMC endocrine disorders · 2026Article
- Association ofFrontiers in cellular and infection microbiology · 2026Article
- Prevalence, Risk Factors, and Endoscopic Findings ofAntibiotics (Basel, Switzerland) · 2025Article
- Association ofBMJ open · 2024Article
- A survey on Helicobacter pylori infection rate in Hainan Province and analysis of related risk factors.BMC gastroenterology · 2023Article
- Helicobacter pylori infection in pediatrics with gastrointestinal complaints.International journal of physiology, pathophysiology and pharmacology · 2022Article
- Article
- Article
- Functional Dyspepsia: A Narrative Review With a Focus on Sex-Gender Differences.Journal of neurogastroenterology and motility · 2020Review
- Sex differences in urea breath test results for the diagnosis of Helicobacter pylori infection: a large cross-sectional study.Biology of sex differences · 2018Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo verify whether there is a gender difference in the (13)C-urea breath test results in a large cohort.
methodsThe test results of dyspeptic patients referred for (13)C-urea breath testing between January and December, 2007 were evaluated. Testing was carried out at the health insurance organization branches and evaluated at a central laboratory in Israel.
resultsOf a total of 28 746 test results, 18 122 (63.04%) were from females and 10 624 (36.95%) from males. Overall, 10 188 (35.4%) results [expressed as delta over baseline (DOB)] were positive (DOB (13)C > 5), 18,326 (63.7%) were negative (DOB (13)C < 3.5) and 232 (0.8%) were borderline (DOB (13)C 3.5-5). There was a significant difference between the total positive rate among females and males (34.8% vs 37.2%, respectively, P = 0.0003). The mean test value was increased by approximately 10 units for females compared to males (P < 0.01) and this difference was consistent for all age groups (i.e., between 10-80 years of age, P < 0.01).
conclusionMore females were referred to (13)C-urea breath testing. More males had positive results. The mean test values were significantly higher among females of all age groups, possibly representing an increased bacterial load among females and suggesting gender-associated differences in Helicobacter pylori host interactions.
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