Evidence map›Paper›PMID 22737590›Full record

ArticleWorld journal of gastrointestinal pathophysiology2012

Update on pathogenesis and clinical management of acute pancreatitis.

Dulce M Cruz-Santamaría, Carlos Taxonera, Manuel Giner

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastrointestinal pathophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
9.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Efficacy of glucocorticoids in rodents of severe acute pancreatitis: a meta-analysis.International journal of clinical and experimental pathology · 2014
    Pooled it
  2. Pooled it
  3. The Relationship Between PANC-3 Score and Nutritional Risk Screening 2002 Score in Patients with Acute Pancreatitis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026
    Observational
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. THE PANC 3 SCORE PREDICTING SEVERITY OF ACUTE PANCREATITIS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2016
    Article
  13. Article
  14. Article
  15. Significance of resistin expression in acute pancreatitis.Experimental and therapeutic medicine · 2015
    Article
  16. Article
  17. Treatment of severe acute pancreatitis and its complications.World journal of gastroenterology · 2014
    Review
  18. Review
  19. Review
  20. Acute Pancreatitis Caused By Mushroom Poisoning: A Report of Two Cases.Journal of investigative medicine high impact case reports
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dulce M Cruz-SantamaríaDulce M Cruz-Santamaría, Carlos Taxonera, Department of Gastroenterology, Hospital Clínico San Carlos, Complutense University of Madrid, 28040 Madrid, Spain.
Carlos Taxonera
Manuel Giner
Hospital Clínico San Carlos · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute pancreatitis (AP), defined as the acute nonbacterial inflammatory condition of the pancreas, is derived from the early activation of digestive enzymes found inside the acinar cells, with variable compromise of the gland itself, nearby tissues and other organs. So, it is an event that begins with pancreatic injury, elicits an acute inflammatory response, encompasses a variety of complications and generally resolves over time. Different conditions are known to induce this disorder, although the innermost mechanisms and how they act to develop the disease are still unknown. We summarize some well established aspects. A phase sequence has been proposed: etiology factors generate other conditions inside acinar cells that favor the AP development with some systemic events; genetic factors could be involved as susceptibility and modifying elements. AP is a disease with extremely different clinical expressions. Most patients suffer a mild and limited disease, but about one fifth of cases develop multi organ failure, accompanied by high mortality. This great variability in presentation, clinical course and complications has given rise to the confusion related to AP related terminology. However, consensus meetings have provided uniform definitions, including the severity of the illness. The clinical management is mainly based on the disease´s severity and must be directed to correct the underlying predisposing factors and control the inflammatory process itself. The first step is to determine if it is mild or severe. We review the principal aspects to be considered in this treatment, as reflected in several clinical practice guidelines. For the last 25 years, there has been a global increase in incidence of AP, along with many advances in diagnosis and treatment. However, progress in knowledge of its pathogenesis is scarce.

Indexed as

PancreasPancreatitisPathogenesisTreatment

Identifiers

PMID22737590
PMCPMC3382704
OpenAlexW2043125833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.