ArticleIranian Red Crescent medical journal2011
The effect of calendula officinalis in therapy of acetic Acid induced ulcerative colitis in dog as an animal model.
Article in Iranian Red Crescent medical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Preclinical and Limited Clinical Evidence for Spirulina in Ulcerative Colitis: A Systematic Review and Meta-analysis.Advanced pharmaceutical bulletin · 2025Review
- Article
- The Healing Effect of Aloe Vera Gel on Acetic Acid-Induced Ulcerative Colitis in Rat.Middle East journal of digestive diseases · 2020Article
- Effects of Aqueous and Methanolic Extracts of Stem Bark ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- The Healing Effect of Grape Seed Oil Enema with or without Sesame Oil in Acetic Acid Induced Ulcerative Colitis of Rats.World journal of plastic surgery · 2017Article
- Article
- Protective effect of royal jelly in 2,4,6 trinitrobenzene sulfonic acid-induced colitis in rats.Iranian journal of basic medical sciences · 2015Article
- A Bio-Guided Fractionation to Assess the Inhibitory Activity of Calendula officinalis L. on the NF-κB Driven Transcription in Human Gastric Epithelial Cells.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Healing effect of pistacia atlantica fruit oil extract in acetic Acid-induced colitis in rats.Iranian journal of medical sciences · 2014Article
- Anti-inflammatory effect of Helichrysum oligocephalum DC extract on acetic acid - Induced acute colitis in rats.Advanced biomedical research · 2014Article
- The Healing Effect of Teucrium polium in Acetic Acid-Induced Ulcerative Colitis in the Dog as an Animal Model.Middle East journal of digestive diseases · 2012Article
- Healing acceleration of acetic acid-induced colitis by marigold (Calendula officinalis) in male rats.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn patients with ulcerative colitis (UC), the repeated cycle of injury and repair of intestinal mucosa has been reported to increase the risk of colon cancer. So, a safe and efficient therapy is required for the treatment and prophylaxis for the disease.This study aims to investigate the efficacy of Calendula officinalis extract in treatment of experimentally induced ulcerative colitis in dog animal model.
methodsDuring fall 2010, 10 out-bred female German dogs (1-2 years old; weighs of 20-25 kg) were enrolled. Ulcerative colitis was induced with 6% acetic acid as enema and method of treatment was retrograde (via enema) too by C. officinalis.
resultsLoose stools, diarrhea, gross bleeding and loss of body weight happened after administration of acetic acid and crypt damage, loss of epithelium, infiltration of inflammatory cells and depletion of goblet cells were noticed histologically. C. officinalis could successfully resolve the damages of UC.
conclusionTreatment with C. officinalis can broaden the current therapy options for UC.
Indexed as
Identifiers
22737434PMC3371898W2101741463What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.