ArticleScientific reports2012
Polyamine sensitivity of gap junctions is required for skin pattern formation in zebrafish.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Gap junctions in Turing-type periodic feather pattern formation.PLoS biology · 2024Article
- Review
- Bioelectric signaling as a unique regulator of development and regeneration.Development (Cambridge, England) · 2021Review
- Role of the Connexin C-terminus in skin pattern formation of Zebrafish.BBA advances · 2021Article
- Comparative transcriptome analysis of trout skin pigment cells.BMC genomics · 2019Article
- Bioelectrical control of positional information in development and regeneration: A review of conceptual and computational advances.Progress in biophysics and molecular biology · 2018Review
- Gain-of-function mutations in Aqp3a influence zebrafish pigment pattern formation through the tissue environment.Development (Cambridge, England) · 2017Article
- Gap Junction in the Teleost Fish Lineage: Duplicated Connexins May Contribute to Skin Pattern Formation and Body Shape Determination.Frontiers in cell and developmental biology · 2017Review
- Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish.Biology open · 2016Article
- The Physiological Characterization of Connexin41.8 and Connexin39.4, Which Are Involved in the Striped Pattern Formation of Zebrafish.The Journal of biological chemistry · 2016Article
- Connexins and pannexins in the integumentary system: the skin and appendages.Cellular and molecular life sciences : CMLS · 2015Review
- Gap junctions composed of connexins 41.8 and 39.4 are essential for colour pattern formation in zebrafish.eLife · 2014Article
- Bioelectric signaling regulates size in zebrafish fins.PLoS genetics · 2014Article
- Stress and polyamine metabolism in fungi.Frontiers in chemistry · 2013Review
- Gene expression divergence and nucleotide differentiation between males of different color morphs and mating strategies in the ruff.Ecology and evolution · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gap junctions allow the direct and bidirectional transfer of small molecules between cells. Polyamine sensitivity, which has been observed for a certain gap junction in vitro, confers rectification property to gap junction. Here we report that the polyamine sensitivity of gap junctions in vivo is crucial for skin pattern formation in zebrafish. Transgenic experiments have revealed that several connexin genes were able to rescue the spot phenotype of mutant zebrafish. Mutational analyses of the N-terminal region of connexins revealed that the ExxxE motif, a hypothetical polyamine-binding site, was important for connexin's role in pattern formation. Ectopic expression of spermidine/spermine N(1)-acetyltransferase (SSAT), a polyamine metabolic enzyme, also caused stripe pattern changes, which further indicates that the polyamine sensitivity of gap junctions is crucial. This is the first report to show that polyamine sensitivity has a physiologically relevant function and is related to skin pattern formation in animals.
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