ArticleScientific reports2012
Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Effects of Schistosoma haematobium infection and treatment on the systemic and mucosal immune phenotype, gene expression and microbiome: A systematic review.PLoS neglected tropical diseases · 2024Pooled it
- Schistosomiasis vaccine SchistoShield® induces functional immune memory responses in US and African populations.NPJ vaccines · 2026Article
- Acquired Clinical Immunity to Malaria in Nonhuman Primates Coinfected withInfection and immunity · 2022Article
- Altered levels of memory T cell subsets and common γc cytokines in Strongyloides stercoralis infection and partial reversal following anthelmintic treatment.PLoS neglected tropical diseases · 2018Article
- Group 2 ILCs: A way of enhancing immune protection against human helminths?Parasite immunology · 2018Review
- A Strong Humoral Immune Response Induced by a Vaccine Formulation Containing rSm29 Adsorbed to Alum Is Associated With Protection AgainstFrontiers in immunology · 2018Article
- HIV-1 Viral Loads Are Not Elevated in Individuals Co-infected WithFrontiers in immunology · 2018Article
- CD4International journal of hematology · 2017Article
- Long-term Maintenance of CD4 T Cell Memory Responses to Malaria Antigens in Malian Children Coinfected withFrontiers in immunology · 2017Article
- Group 2 innate lymphoid cell proportions are diminished in young helminth infected children and restored by curative anti-helminthic treatment.PLoS neglected tropical diseases · 2015Article
- Differences in the Faecal Microbiome in Schistosoma haematobium Infected Children vs. Uninfected Children.PLoS neglected tropical diseases · 2015Article
- An IL-13 promoter polymorphism associated with liver fibrosis in patients with Schistosoma japonicum.PloS one · 2015Article
- Schistosoma haematobium infection and CD4+ T-cell levels: a cross-sectional study of young South African women.PloS one · 2015Article
- Article
- DNA methylation changes separate allergic patients from healthy controls and may reflect altered CD4+ T-cell population structure.PLoS genetics · 2014Article
- Article
- Infection and treatment immunizations for successful parasite vaccines.Trends in parasitology · 2013Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
Characterisation of protective helminth acquired immunity in humans or experimental models has focused on effector responses with little work conducted on memory responses. Here we show for the first time, that human helminth infection is associated with altered proportions of the CD4+ memory T cells, with an associated alteration of T(H)1 responses. The reduced CD4+ memory T cell proportions are associated with a significantly lower ratio of schistosome-specific IgE/IgG4 (marker for resistance to infection/re-infection) in uninfected older people. Helminth infection does not affect the CD8+ memory T cell pool. Furthermore, we show for the first time in a helminth infection that the CD4+ memory T cell proportions decline following curative anti-helminthic treatment despite increased CD4+ memory cell replication. Reduced accumulation of the CD4+ memory T cells in schistosome-infected people has implications for the development of natural or vaccine induced schistosome-specific protective immunity as well as for unrelated pathogens.
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