ArticleJournal of Korean Neurosurgical Society2012
The neuroprotective effect of treatment of valproic Acid in acute spinal cord injury.
Article in Journal of Korean Neurosurgical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The impact of histone deacetylase inhibition on neurobehavioural outcomes in preclinical models of traumatic and non-traumatic spinal cord injury: a systematic review.Frontiers in immunology · 2025Pooled it
- Early Decompression in Acute Spinal Cord Injury : Review and Update.Journal of Korean Neurosurgical Society · 2023Article
- An aqueous extract ofHeliyon · 2022Article
- The Modulation of Neurotrophin and Epigenetic Regulators: Implication for Astrocyte Proliferation and Neuronal Cell Apoptosis After Spinal Cord Injury.Annals of rehabilitation medicine · 2016Article
- Effects of tumor necrosis factor alpha blocker adalimumab in experimental spinal cord injury.Journal of Korean Neurosurgical Society · 2015Article
- Neuroprotective effect of ginseng against spinal cord injury induced oxidative stress and inflammatory responses.International journal of clinical and experimental medicine · 2015Article
- Decreased GFAP expression and improved functional recovery in contused spinal cord of rats following valproic acid therapy.Neurochemical research · 2014Article
- The neuroprotective effect of treatment with curcumin in acute spinal cord injury: laboratory investigation.Neurologia medico-chirurgica · 2014Article
- Valproic Acid increases expression of neuronal stem/progenitor cell in spinal cord injury.Journal of Korean Neurosurgical Society · 2013Article
- Epigenetic regulation in the brain after spinal cord injury : a comparative study.Journal of Korean Neurosurgical Society · 2013Article
- Valproic acid attenuates microgliosis in injured spinal cord and purinergic P2X4 receptor expression in activated microglia.Journal of neuroscience research · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveValproic acid (VPA), as known as histone deacetylase inhibitor, has neuroprotective effects. This study investigated the histological changes and functional recovery from spinal cord injury (SCI) associated with VPA treatment in a rat model.
methodsLocomotor function was assessed according to the Basso-Beattie-Bresnahan scale for 2 weeks in rats after receiving twice daily intraperitoneal injections of 200 mg/kg VPA or the equivalent volume of normal saline for 7 days following SCI. The injured spinal cord was then examined histologically, including quantification of cavitation.
resultsBasso-Beattie-Bresnahan scale scores in rats receiving VPA were significantly higher than in the saline group (p<0.05). The cavity volume in the VPA group was significantly reduced compared with the control (saline-injected) group (p<0.05). The level of histone acetylation recovered in the VPA group, while it was significantly decreased in the control rats (p<0.05). The macrophage level was significantly decreased in the VPA group (p<0.05).
conclusionVPA influences the restoration of hyperacetylation and reduction of the inflammatory reaction resulting from SCI, and is effective for histology and motor function recovery.
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