ArticlePloS one2012
Testosterone is associated with erectile dysfunction: a cross-sectional study in Chinese men.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Efficacy of continuous positive airway pressure on testosterone in men with obstructive sleep apnea: a meta-analysis.PloS one · 2014Pooled it
- Edible Bird Nest Supplementation Enhances Male Reproductive Function: Current Insights and Future Horizons.Foods (Basel, Switzerland) · 2025Review
- Erectile dysfunction predictors in hypertensives at a primary care clinic in Southern Nigeria.African journal of primary health care & family medicine · 2022Article
- Association of total and calculated free testosterone with androgen deficiency symptoms in patients with type 2 diabetes.International journal of impotence research · 2020Article
- Drinking Frequency but not Years may be Associated with Lower Urinary Tract Symptoms: Result from a Large Cross-Sectional Survey in Chinese Men.Risk management and healthcare policy · 2020Article
- Free testosterone correlated with erectile dysfunction severity among young men with normal total testosterone.International journal of impotence research · 2019Article
- Potential Protective Effect of Osteocalcin in Middle-Aged Men with Erectile Dysfunction: Evidence from the FAMHES Project.Scientific reports · 2018Article
- Physical activity and prevalence of erectile dysfunction in Japanese patients with type 2 diabetes mellitus: The Dogo Study.Journal of diabetes investigation · 2018Article
- Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Immunization associated with erectile dysfunction based on cross-sectional and genetic analyses.PloS one · 2014Article
- Association between serum ferritin levels and risk of the metabolic syndrome in Chinese adults: a population study.PloS one · 2013Article
- The association between the levels of serum ferritin and sex hormones in a large scale of Chinese male population.PloS one · 2013Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTestosterone is essential for the regulation of erectile physiology, but the relationship between low testosterone and erectile dysfunction (ED) has not been firmly established. PURPOSE: To examine the association between serum total, free and bio-available testosterone and ED in a population-based sample.
methodsA consecutive series of 1776 men aged 20-77 participated in the routine physical examination from September 2009 to December 2009 in Guangxi, China. ED was assessed using the five-item International Index of Erectile Function (IIEF-5) questionnaire. Total testosterone (TT), sex hormone binding globulin (SHBG) and other biochemical profiles were measured. Free testosterone (FT) and bio-available testosterone (BT) were calculated based on Vermeulen's formula. Data were collected with regard to smoking, alcoholic drinking, physical activity and metabolic syndrome.
resultsThe prevalence of ED (IIEF-5<22) was 47.6%. Men with ED were significantly older, and more prone to smoke cigarettes (≥20 cigarettes/day) or drink alcohol (≥3 drinks/week), and more likely to have elevated blood pressure (P = 0.036) or hyperglycemia (P<0.001) compared with those without ED. The significant increase in SHBG with age was parallel to its increase with increasing severity of ED (P<0.001). The obscure increase in TT across the ED status was detected without significance (P = 0.418), but TT was positively associated with ED after adjustment for age [odds ratio (OR) = 1.02, 95% CI (confidence internal): 1.00-1.04]. FT and BT were inversely associated with ED (OR = 0.14, 95%CI: 0.06-0.33; OR = 0.92 (95%CI: 0.89-0.96, respectively) in the univariate analysis, and this inverse association appeared to be independent of smoking status, alcoholic drinking, physical activity, hyper-triglyceridemia and hyperglycemia.
conclusionsFT and BT are inversely related to worsening ED, whereas the positive association between TT and ED is most likely due to the increase in SHBG.
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