ArticlePloS one2012
PCSK1 rs6232 is associated with childhood and adult class III obesity in the Mexican population.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals.Human molecular genetics · 2015Pooled it
- Contribution of common PCSK1 genetic variants to obesity in 8,359 subjects from multi-ethnic American population.PloS one · 2013Pooled it
- Association ofGenes · 2023Article
- Dietary Sugar Research in Preschoolers: Methodological, Genetic, and Cardiometabolic Considerations.Reviews in cardiovascular medicine · 2023Review
- Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children.International journal of molecular sciences · 2020Article
- Genome-Wide Association Study of Body Mass Index and Body Fat in Mexican-Mestizo Children.Genes · 2019Article
- Reduced Stability and pH-Dependent Activity of a Common Obesity-Linked PCSK1 Polymorphism, N221D.Endocrinology · 2019Article
- Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment.The Journal of clinical endocrinology and metabolism · 2018Article
- Article
- PCSK1 Variants and Human Obesity.Progress in molecular biology and translational science · 2016Review
- Common variants in PCSK1 influence blood pressure and body mass index.Journal of human hypertension · 2015Article
- Polymorphisms in FTO, TMEM18 and PCSK1 are associated with BMI in southern Chinese population.Journal of genetics · 2014Article
- Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function.Endocrinology · 2014Article
- Association of genetic variants of the incretin-related genes with quantitative traits and occurrence of type 2 diabetes in Japanese.Molecular genetics and metabolism reports · 2014Article
- Contribution of common genetic variants to obesity and obesity-related traits in mexican children and adults.PloS one · 2013Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCommon variants rs6232 and rs6235 in the PCSK1 gene have been associated with obesity in European populations. We aimed to evaluate the contribution of these variants to obesity and related traits in Mexican children and adults. METHODOLOGY/PRINCIPAL
findingsRs6232 and rs6235 were genotyped in 2382 individuals, 1206 children and 1176 adults. Minor allele frequencies were 0.78% for rs6232 and 19.99% for rs6235. Rs6232 was significantly associated with childhood obesity and adult class III obesity (OR = 3.01 95%CI 1.64-5.53; P = 4 × 10⁻⁴ in the combined analysis). In addition, this SNP was significantly associated with lower fasting glucose levels (P = 0.01) and with increased insulin levels and HOMA-B (P = 0.05 and 0.01, respectively) only in non-obese children. In contrast, rs6235 showed no significant association with obesity or with glucose homeostasis parameters in any group. CONCLUSION/SIGNIFICANCE: Although rs6232 is rare in the Mexican population, it should be considered as an important risk factor for extreme forms of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.