ArticlePloS one2012
Differential selection on carotenoid biosynthesis genes as a function of gene position in the metabolic pathway: a study on the carrot and dicots.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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23 citing papers in PubMed.
- Biotic interactions, evolutionary forces and the pan-plant specialized metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Chlorophyll and Carotenoid Metabolism Varies with Growth Temperatures among Tea Genotypes with Different Leaf Colors inInternational journal of molecular sciences · 2024Article
- The genetic mechanisms underlying the convergent evolution of pollination syndromes in the Neotropical radiation ofFrontiers in plant science · 2022Article
- Structure and contingency determine mutational hotspots for flower color evolution.Evolution letters · 2021Article
- QTL analysis and GWAS of agronomic traits in sweetpotato (Breeding science · 2020Article
- Evolutionary rate variation among genes involved in galactomannan biosynthesis inEcology and evolution · 2020Article
- A multiscale approach to detect selection in nonmodel tree species: Widespread adaptation despite population decline inEvolutionary applications · 2020Article
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- Molecular Evolution of GDP-D-Mannose Epimerase (Frontiers in plant science · 2018Article
- The factors affecting the evolution of the anthocyanin biosynthesis pathway genes in monocot and dicot plant species.BMC plant biology · 2017Article
- Carotenoid gene expression explains the difference of carotenoid accumulation in carrot root tissues.Planta · 2017Article
- Domestication and the storage starch biosynthesis pathway: signatures of selection from a whole sorghum genome sequencing strategy.Plant biotechnology journal · 2016Article
- Evolutionary patterns of Toll-like receptor signaling pathway genes in the Suidae.BMC evolutionary biology · 2016Article
- Evolutionary Rate Heterogeneity of Primary and Secondary Metabolic Pathway Genes in Arabidopsis thaliana.Genome biology and evolution · 2015Article
- Sequence diversity and differential expression of major phenylpropanoid-flavonoid biosynthetic genes among three mango varieties.BMC genomics · 2015Article
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- Evolutionary study of the isoflavonoid pathway based on multiple copies analysis in soybean.BMC genetics · 2014Article
- Molecular evolution of multiple-level control of heme biosynthesis pathway in animal kingdom.PloS one · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSelection of genes involved in metabolic pathways could target them differently depending on the position of genes in the pathway and on their role in controlling metabolic fluxes. This hypothesis was tested in the carotenoid biosynthesis pathway using population genetics and phylogenetics. METHODOLOGY/PRINCIPAL
findingsEvolutionary rates of seven genes distributed along the carotenoid biosynthesis pathway, IPI, PDS, CRTISO, LCYB, LCYE, CHXE and ZEP, were compared in seven dicot taxa. A survey of deviations from neutrality expectations at these genes was also undertaken in cultivated carrot (Daucus carota subsp. sativus), a species that has been intensely bred for carotenoid pattern diversification in its root during its cultivation history. Parts of sequences of these genes were obtained from 46 individuals representing a wide diversity of cultivated carrots. Downstream genes exhibited higher deviations from neutral expectations than upstream genes. Comparisons of synonymous and nonsynonymous substitution rates between genes among dicots revealed greater constraints on upstream genes than on downstream genes. An excess of intermediate frequency polymorphisms, high nucleotide diversity and/or high differentiation of CRTISO, LCYB1 and LCYE in cultivated carrot suggest that balancing selection may have targeted genes acting centrally in the pathway. CONCLUSIONS/SIGNIFICANCE: Our results are consistent with relaxed constraints on downstream genes and selection targeting the central enzymes of the carotenoid biosynthesis pathway during carrot breeding history.
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