ArticleGastroenterology research and practice2012
Bone mineralization in celiac disease.
Article in Gastroenterology research and practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Newly Diagnosed Celiac Disease and Bone Health in Young Adults: A Systematic Literature Review.Calcified tissue international · 2022Pooled it
- Bones of contention: bone mineral density recovery in celiac disease--a systematic review.Nutrients · 2015Pooled it
- Primary Hyperparathyroidism in Celiac Disease: Diagnostic Challenges and Therapeutic Strategies.Nutrients · 2026Review
- Menopause and gastrointestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2025Review
- Investigation of the frequency of molar incisor hypomineralisation in childhood celiac disease and evaluation with nutritional factors and calcium metabolism.Frontiers in pediatrics · 2025Article
- Review
- Osteoporosis and Celiac Disease: Updates and Hidden Pitfalls.Nutrients · 2023Review
- A Comprehensive Review of the Neurological Manifestations of Celiac Disease and Its Treatment.Diseases (Basel, Switzerland) · 2022Review
- Celiac disease and bone.Archives of endocrinology and metabolism · 2022Review
- The Impact of Celiac Disease on Complication Rates After Total Joint Arthroplasty: A Matched Cohort Study.Arthroplasty today · 2022Article
- Bone Fragility in Gastrointestinal Disorders.International journal of molecular sciences · 2022Review
- Bone Loss Correlated with Parathyroid Hormone Levels in Adult Celiac Patients.Middle East journal of digestive diseases · 2022Article
- Bone Mineral Density Screening and the Frequency of Osteopenia/Osteoporosis in Turkish Adult Patients With Celiac Disease.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Article
- Fracture risk assessment in celiac disease: a registry-based cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- The Prevalence of Celiac Disease in a Fracture Liaison Service Population.Calcified tissue international · 2020Article
- Celiac Disease: Extraintestinal Manifestations and Associated Conditions.Journal of clinical gastroenterology · 2020Review
- Gluten-Induced Extra-Intestinal Manifestations in Potential Celiac Disease-Celiac Trait.Nutrients · 2019Review
- Neutrophil-to-Lymphocyte Ratio, Mediterranean Diet, and Bone Health in Coeliac Disease Patients: A Pilot Study.Oxidative medicine and cellular longevity · 2019Article
- Celiac Disease-Musculoskeletal Manifestations and Mechanisms in Children to Adults.Current osteoporosis reports · 2018Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence indicates a well-established relationship between low bone mineral density (BMD) and celiac disease (CD), but data on the pathogenesis of bone derangement in this setting are still inconclusive. In patients with symptomatic CD, low BMD appears to be directly related to the intestinal malabsorption. Adherence to a strict gluten-free diet (GFD) will reverse the histological changes in the intestine and also the biochemical evidence of calcium malabsorption, resulting in rapid increase of BMD. Nevertheless, GFD improves BMD but does not normalize it in all patients, even after the recovery of intestinal mucosa. Other mechanisms of bone injury than calcium and vitamin D malabsorption are thought to be involved, such as proinflammatory cytokines, parathyroid function abnormalities, and misbalanced bone remodeling factors, most of all represented by the receptor activator of nuclear factor B/receptor activator of nuclear factor B-ligand/osteoprotegerin system. By means of dual-energy X-ray absorptiometry (DXA), it is now rapid and easy to obtain semiquantitative values of BMD. However, the question is still open about who and when submit to DXA evaluation in CD, in order to estimate risk of fractures. Furthermore, additional information on the role of nutritional supplements and alternative therapies is needed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.