ArticleFrontiers in plant science2012
Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models.
Article in Frontiers in plant science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
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- To have or not to have: expression of amino acid transporters during pathogen infection.Plant molecular biology · 2022Review
- Root Membrane Ubiquitinome under Short-Term Osmotic Stress.International journal of molecular sciences · 2022Article
- Carbon/nitrogen metabolism and stress response networks - calcium-dependent protein kinases as the missing link?Journal of experimental botany · 2021Review
- ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes.Frontiers in plant science · 2021Review
- The Arabidopsis L-Type Amino Acid Transporter 5 (LAT5/PUT5) Is Expressed in the Phloem and Alters Seed Nitrogen Content When Knocked Out.Plants (Basel, Switzerland) · 2020Article
- The Arabidopsis Plastidial Glucose-6-Phosphate Transporter GPT1 is Dually Targeted to Peroxisomes via the Endoplasmic Reticulum.The Plant cell · 2020Article
- Proteome-wide, Structure-Based Prediction of Protein-Protein Interactions/New Molecular Interactions Viewer.Plant physiology · 2019Article
- The PIN-FORMED Auxin Efflux Carriers in Plants.International journal of molecular sciences · 2018Review
- The Interactomic Analysis Reveals Pathogenic Protein Networks inFrontiers in genetics · 2018Article
- The Vacuolar Protein Sorting-38 Subunit of theFrontiers in plant science · 2018Article
- Comprehensive genomic analysis of the CNGC gene family in Brassica oleracea: novel insights into synteny, structures, and transcript profiles.BMC genomics · 2017Article
- Novel Aquaporin Regulatory Mechanisms Revealed by Interactomics.Molecular & cellular proteomics : MCP · 2016Article
- Techniques for the Analysis of Protein-Protein Interactions in Vivo.Plant physiology · 2016Review
- Article
- Identification of rice cornichon as a possible cargo receptor for the Golgi-localized sodium transporter OsHKT1;3.Journal of experimental botany · 2015Article
- The female gametophyte: an emerging model for cell type-specific systems biology in plant development.Frontiers in plant science · 2015Review
- A predicted protein interactome identifies conserved global networks and disease resistance subnetworks in maize.Frontiers in genetics · 2015Article
- Expression of a translationally fused TAP-tagged plasma membrane proton pump in Arabidopsis thaliana.Biochemistry · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-throughput data are a double-edged sword; for the benefit of large amount of data, there is an associated cost of noise. To increase reliability and scalability of high-throughput protein interaction data generation, we tested the efficacy of classification to enrich potential protein-protein interactions. We applied this method to identify interactions among Arabidopsis membrane proteins enriched in transporters. We validated our method with multiple retests. Classification improved the quality of the ensuing interaction network and was effective in reducing the search space and increasing true positive rate. The final network of 541 interactions among 239 proteins (of which 179 are transporters) is the first protein interaction network enriched in membrane transporters reported for any organism. This network has similar topological attributes to other published protein interaction networks. It also extends and fills gaps in currently available biological networks in plants and allows building a number of hypotheses about processes and mechanisms involving signal-transduction and transport systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.