ArticleFrontiers in endocrinology2012
The conductor of the autonomic orchestra.
Article in Frontiers in endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Nocturnal heart rate during sleep is associated with increased risk of type 2 diabetes mellitus in adults with obstructive sleep apnoea syndrome.Annals of medicine · 2025Article
- Autonomic neuropathy in diabetes.Archives of endocrinology and metabolism · 2025Review
- Machine Learning Classification of Pediatric Health Status Based on Cardiorespiratory Signals with Causal and Information Domain Features Applied-An Exploratory Study.Journal of clinical medicine · 2024Article
- How to properly evaluate cardiac vagal tone in oncology studies: a state-of-the-art review.Journal of the National Cancer Center · 2024Review
- Neurological dysfunction screening in a cohort of adolescents with type 1 diabetes: a six-year follow-up.Frontiers in medicine · 2024Article
- Autonomic and Somatic Nerve Functions in Type 2 Diabetes Mellitus Patients: Electrophysiological Aspects.Diagnostics (Basel, Switzerland) · 2021Article
- Cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus and its association with serum omentin and leptin.Journal of family medicine and primary care · 2020Article
- Cardiovascular risk, lifestyle and anthropometric status of rural workers in Pardo River Valley, Rio Grande do Sul, Brazil.Revista brasileira de medicina do trabalho : publicacao oficial da Associacao Nacional de Medicina do Trabalho-ANAMT · 2020Article
- Involvement of Acetylcholine Receptors in Cholinergic Pathway-Mediated Protection Against Autoimmune Diabetes.Frontiers in immunology · 2019Article
- β-Cell mass restoration by α7 nicotinic acetylcholine receptor activation.The Journal of biological chemistry · 2018Article
- Heart-rate variability: a biomarker to study the influence of nutrition on physiological and psychological health?Behavioural pharmacology · 2018Review
- Effects of High-Dose α-Lipoic Acid on Heart Rate Variability of Type 2 Diabetes Mellitus Patients with Cardiac Autonomic Neuropathy in Korea.Diabetes & metabolism journal · 2017Article
- Can coefficient of variation of time-domain analysis be valuable for detecting cardiovascular autonomic neuropathy in young patients with type 1 diabetes: a case control study.BMC cardiovascular disorders · 2017Article
- Spinal cord injury modulates the lung inflammatory response in mechanically ventilated rats: a comparative animal study.Physiological reports · 2016Article
- Article
- The Role of Gut Microflora and the Cholinergic Anti-inflammatory Neuroendocrine System in Diabetes Mellitus.Frontiers in endocrinology · 2016Review
- Vitamin D Insufficiency is Associated with Reduced Parasympathetic Nerve Fiber Function in Type 2 Diabetes.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2015Article
- Cardiorespiratory coupling: common rhythms in cardiac, sympathetic, and respiratory activities.Progress in brain research · 2014Review
- Autonomic neuropathy in diabetes mellitus.Frontiers in endocrinology · 2014Review
- Impact of glycemic control on heart rate variability in youth with type 1 diabetes: the SEARCH CVD study.Diabetes technology & therapeutics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bad bedfellows - autonomic dysfunction, inflammation, and diabetes! Are they related? How? Evidence suggests the activation of inflammatory cytokines like IL-6 and TNFα in newly diagnosed type 2 diabetes and that the inflammatory change correlates with abnormalities in sympathovagal balance. Dysfunction of the autonomic system predicts cardiovascular risk and sudden death in patients with type 2 diabetes. It occurs in prediabetes, providing opportunities for early intervention. The importance of recognizing autonomic dysfunction as a predictor of morbidity and mortality with intensification of treatment suggests that all patients with type 2 diabetes at onset, and those with type 1 diabetes after 5 years should be screened for autonomic imbalance. These tests can be performed at the bedside with real time output of information - within the scope of the practicing physician - facilitates diagnosis and allows the application of sound strategies for management. The window of opportunity for aggressive control of all the traditional risk factors for cardiovascular events or sudden death with intensification of therapy is with short duration diabetes, the absence of cardiovascular disease, and a history of severe hypoglycemic events. To this list we can now add autonomic dysfunction and neuropathy, which have become the most powerful predictors of risk for mortality. It seems prudent that practitioners should be encouraged to become familiar with this information and apply risk stratification in clinical practice. After all, how difficult is it to ask patients "do you have numb feet?" and to determine their heart rate variability - it could be lifesaving. Ultimately methods to reset the hypothalamus and the inflammatory cascade are needed if we are to impact the care of patients with this compendium of conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.