ArticlePLoS genetics2012
Preferential genome targeting of the CBP co-activator by Rel and Smad proteins in early Drosophila melanogaster embryos.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- Enhancer binding kinetics explain transcription factor hub formation.Science advances · 2026Article
- Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer-factor-mediated zygotic genome activation.Molecular cell · 2025Article
- Tissue-specific RNA Polymerase II promoter-proximal pause release and burst kinetics in a Drosophila embryonic patterning network.Genome biology · 2024Article
- Stepwise modifications of transcriptional hubs link pioneer factor activity to a burst of transcription.Nature communications · 2023Article
- Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity.Nature communications · 2021Article
- Fra-1 regulates its target genes via binding to remote enhancers without exerting major control on chromatin architecture in triple negative breast cancers.Nucleic acids research · 2021Article
- The Core Promoter Is a Regulatory Hub for Developmental Gene Expression.Frontiers in cell and developmental biology · 2021Review
- Multiple mechanisms regulate H3 acetylation of enhancers in response to thyroid hormone.PLoS genetics · 2020Article
- Gene activation by dCas9-CBP and the SAM system differ in target preference.Scientific reports · 2019Article
- Enhancer RNA and NFκB-dependent P300 regulation of ADAMDEC1.Molecular immunology · 2018Article
- Multiple functions of CREB-binding protein during postembryonic development: identification of target genes.BMC genomics · 2017Article
- CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II.Molecular cell · 2017Article
- Mechanisms of Groucho-mediated repression revealed by genome-wide analysis of Groucho binding and activity.BMC genomics · 2017Article
- Drosophila poised enhancers are generated during tissue patterning with the help of repression.Genome research · 2017Article
- Genome-wide identification of Drosophila dorso-ventral enhancers by differential histone acetylation analysis.Genome biology · 2016Article
- Initiation of diverse epigenetic states during nuclear programming of the Drosophila body plan.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Structure-Function Analysis of the Drosophila melanogaster Caudal Transcription Factor Provides Insights into Core Promoter-preferential Activation.The Journal of biological chemistry · 2015Article
- Eukaryotic enhancers: common features, regulation, and participation in diseases.Cellular and molecular life sciences : CMLS · 2015Review
- P-TEFb, the super elongation complex and mediator regulate a subset of non-paused genes during early Drosophila embryo development.PLoS genetics · 2015Article
- CBP binding outside of promoters and enhancers in Drosophila melanogaster.Epigenetics & chromatin · 2015Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CBP and the related p300 protein are widely used transcriptional co-activators in metazoans that interact with multiple transcription factors. Whether CBP/p300 occupies the genome equally with all factors or preferentially binds together with some factors is not known. We therefore compared Drosophila melanogaster CBP (nejire) ChIP-seq peaks with regions bound by 40 different transcription factors in early embryos, and we found high co-occupancy with the Rel-family protein Dorsal. Dorsal is required for CBP occupancy in the embryo, but only at regions where few other factors are present. CBP peaks in mutant embryos lacking nuclear Dorsal are best correlated with TGF-ß/Dpp-signaling and Smad-protein binding. Differences in CBP occupancy in mutant embryos reflect gene expression changes genome-wide, but CBP also occupies some non-expressed genes. The presence of CBP at silent genes does not result in histone acetylation. We find that Polycomb-repressed H3K27me3 chromatin does not preclude CBP binding, but restricts histone acetylation at CBP-bound genomic sites. We conclude that CBP occupancy in Drosophila embryos preferentially overlaps factors controlling dorso-ventral patterning and that CBP binds silent genes without causing histone hyperacetylation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.