ArticlePLoS computational biology2012
Short term synaptic depression imposes a frequency dependent filter on synaptic information transfer.
Article in PLoS computational biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Increased firing rates monotonically expand neuronal coding bandwidth.Biological cybernetics · 2026Article
- Frequency-dependent coupling in response to oscillatory inputs in minimal networks of electrically coupled nodes: Gap junction networks and spatially extended neurons.Biological cybernetics · 2026Article
- Homeostatic Plasticity Enables Stable yet Tunable Neuronal Assemblies.bioRxiv : the preprint server for biology · 2026Article
- Optogenetic circuit mapping reveals connectivity and synaptic physiology of T-stellate projections from the cochlear nucleus to the auditory midbrain.bioRxiv : the preprint server for biology · 2026Article
- Postsynaptic frequency filters shaped by the interplay of synaptic short-term plasticity and cellular time scales.Journal of computational neuroscience · 2025Article
- Inferring synaptic transmission from the stochastic dynamics of the quantal content: An analytical approach.PLoS computational biology · 2025Article
- Short-term plasticity and context-dependent circuit function: Insights from retinal circuitry.Science advances · 2024Review
- Exact Distribution of the Quantal Content in Synaptic Transmission.Physical review letters · 2024Article
- Spike rate dependent synaptic characteristics in lamellar, multilayered alpha-MoORSC advances · 2024Article
- The spike-timing-dependent plasticity of VIP interneurons in motor cortex.Frontiers in cellular neuroscience · 2024Article
- Sampling-based Bayesian inference in recurrent circuits of stochastic spiking neurons.Nature communications · 2023Article
- Recovery kinetics of short-term depression of GABAergic and glutamatergic synapses at layer 2/3 pyramidal cells in the mouse barrel cortex.Frontiers in cellular neuroscience · 2023Article
- Mesoscopic description of hippocampal replay and metastability in spiking neural networks with short-term plasticity.PLoS computational biology · 2022Article
- Auditory cortex modelled as a dynamical network of oscillators: understanding event-related fields and their adaptation.Biological cybernetics · 2022Article
- Pre- and postsynaptically expressed spike-timing-dependent plasticity contribute differentially to neuronal learning.PLoS computational biology · 2022Article
- Multiscale modeling of presynaptic dynamics from molecular to mesoscale.PLoS computational biology · 2022Article
- A theory of synaptic transmission.eLife · 2021Article
- Article
- Review
- Differential Short-Term Plasticity of PV and SST Neurons Accounts for Adaptation and Facilitation of Cortical Neurons to Auditory Tones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
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3 authors.
Funding
Abstract
Depletion of synaptic neurotransmitter vesicles induces a form of short term depression in synapses throughout the nervous system. This plasticity affects how synapses filter presynaptic spike trains. The filtering properties of short term depression are often studied using a deterministic synapse model that predicts the mean synaptic response to a presynaptic spike train, but ignores variability introduced by the probabilistic nature of vesicle release and stochasticity in synaptic recovery time. We show that this additional variability has important consequences for the synaptic filtering of presynaptic information. In particular, a synapse model with stochastic vesicle dynamics suppresses information encoded at lower frequencies more than information encoded at higher frequencies, while a model that ignores this stochasticity transfers information encoded at any frequency equally well. This distinction between the two models persists even when large numbers of synaptic contacts are considered. Our study provides strong evidence that the stochastic nature neurotransmitter vesicle dynamics must be considered when analyzing the information flow across a synapse.
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