ArticlePLoS computational biology2012
Potassium starvation in yeast: mechanisms of homeostasis revealed by mathematical modeling.
Article in PLoS computational biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Molecular architecture of the fungal-specific potassium channel TOK1.Nature communications · 2026Article
- Potassium ion homeostasis modulates mitochondrial function.The Journal of cell biology · 2026Article
- Molecular bases of circadian magnesium rhythms across eukaryotes.FEBS letters · 2026Article
- The structure-dependent effects of newly synthesised cationic gemini surfactants against yeast cells.Scientific reports · 2025Article
- Multi-physics modeling for ion homeostasis in multi-compartment plant cells using an energy function.PLoS computational biology · 2025Article
- Data integration strategies for whole-cell modeling.FEMS yeast research · 2024Review
- Effect of halo-tolerance gene Hal5 on ethanol tolerance ofBBA advances · 2024Article
- The Hrk1 kinase is a determinant of acetic acid tolerance in yeast by modulating HMicrobial cell (Graz, Austria) · 2023Article
- Article
- Article
- Involvement of Protein Kinase CgSat4 in Potassium Uptake, Cation Tolerance, and Full Virulence inFrontiers in plant science · 2022Article
- Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis.Nature communications · 2020Article
- Potassium restriction boosts vacuolar acidity and extends lifespan in yeast.Experimental gerontology · 2019Article
- Evolutionary engineering inBiotechnology for biofuels · 2019Article
- Pleiotropic Roles of ChSat4 in Asexual Development, Cell Wall Integrity Maintenance, and Pathogenicity inFrontiers in microbiology · 2018Article
- Learning (from) the errors of a systems biology model.Scientific reports · 2016Article
- Potassium Uptake Mediated by Trk1 Is Crucial for Candida glabrata Growth and Fitness.PloS one · 2016Article
- A Thermodynamic Model of Monovalent Cation Homeostasis in the Yeast Saccharomyces cerevisiae.PLoS computational biology · 2016Article
- Coordination of K+ transporters in neurospora: TRK1 is scarce and constitutive, while HAK1 is abundant and highly regulated.Eukaryotic cell · 2013Article
- Regulation of cation balance in Saccharomyces cerevisiae.Genetics · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intrinsic ability of cells to adapt to a wide range of environmental conditions is a fundamental process required for survival. Potassium is the most abundant cation in living cells and is required for essential cellular processes, including the regulation of cell volume, pH and protein synthesis. Yeast cells can grow from low micromolar to molar potassium concentrations and utilize sophisticated control mechanisms to keep the internal potassium concentration in a viable range. We developed a mathematical model for Saccharomyces cerevisiae to explore the complex interplay between biophysical forces and molecular regulation facilitating potassium homeostasis. By using a novel inference method ("the reverse tracking algorithm") we predicted and then verified experimentally that the main regulators under conditions of potassium starvation are proton fluxes responding to changes of potassium concentrations. In contrast to the prevailing view, we show that regulation of the main potassium transport systems (Trk1,2 and Nha1) in the plasma membrane is not sufficient to achieve homeostasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.