ArticleSensors (Basel, Switzerland)2012
Size matters: problems and advantages associated with highly miniaturized sensors.
Article in Sensors (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
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- Current state of the art and future directions for implantable sensors in medical technology: Clinical needs and engineering challenges.APL bioengineering · 2023Review
- Portable Waveguide-Based Optical Biosensor.Biosensors · 2022Article
- Sensing beyond Senses: An Overview of Outstanding Strides in Architecting Nanopolymer-Enabled Sensors for Biomedical Applications.Polymers · 2022Review
- Advancement inBiosensors · 2021Review
- Surface Enhanced Raman Spectroscopy With Electrodeposited Copper Ultramicro-Wires With/Without Silver Nanostars Decoration.Nanomaterials (Basel, Switzerland) · 2021Article
- Nanoplasmonic-Nanofluidic Single-Molecule Biosensors for Ultrasmall Sample Volumes.ACS sensors · 2021Article
- Advances in Sensor Technologies in the Era of Smart Factory and Industry 4.0.Sensors (Basel, Switzerland) · 2020Review
- Effects of Air Cavity in Dynamic Pressure Sensors: Experimental Validation.Sensors (Basel, Switzerland) · 2020Article
- Nanohole array plasmonic biosensors: Emerging point-of-care applications.Biosensors & bioelectronics · 2019Review
- Nanoplasmonic Sensor Detects Preferential Binding of IRSp53 to Negative Membrane Curvature.Frontiers in chemistry · 2019Article
- Technological Challenges and Future Issues for the Detection of Circulating MicroRNAs in Patients With Cancer.Frontiers in chemistry · 2019Review
- LSPR and Interferometric Sensor Modalities Combined Using a Double-Clad Optical Fiber.Sensors (Basel, Switzerland) · 2018Article
- Detecting Selective Protein Binding Inside Plasmonic Nanopores: Toward a Mimic of the Nuclear Pore Complex.Frontiers in chemistry · 2018Article
- Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing.Light, science & applications · 2017Article
- Polarization-resolved mechanistic investigation of fluorescence signal intensification on zinc oxide nanorod ends.Nanoscale · 2017Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is no doubt that the recent advances in nanotechnology have made it possible to realize a great variety of new sensors with signal transduction mechanisms utilizing physical phenomena at the nanoscale. Some examples are conductivity measurements in nanowires, deflection of cantilevers and spectroscopy of plasmonic nanoparticles. The fact that these techniques are based on the special properties of nanostructural entities provides for extreme sensor miniaturization since a single structural unit often can be used as transducer. This review discusses the advantages and problems with such small sensors, with focus on biosensing applications and label-free real-time analysis of liquid samples. Many aspects of sensor design are considered, such as thermodynamic and diffusion aspects on binding kinetics as well as multiplexing and noise issues. Still, all issues discussed are generic in the sense that the conclusions apply to practically all types of surface sensitive techniques. As a counterweight to the current research trend, it is argued that in many real world applications, better performance is achieved if the active sensor is larger than that in typical nanosensors. Although there are certain specific sensing applications where nanoscale transducers are necessary, it is argued herein that this represents a relatively rare situation. Instead, it is suggested that sensing on the microscale often offers a good compromise between utilizing some possible advantages of miniaturization while avoiding the complications. This means that ensemble measurements on multiple nanoscale sensors are preferable instead of utilizing a single transducer entity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.