ArticleCancer2012
The risk of hepatocellular carcinoma among individuals with acquired immunodeficiency syndrome in the United States.
Article in Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 68 citations in OpenAlex.
- HIV, Viral Hepatitis, and Schistosomiasis Association with Liver Cancer: A Systematic Review.Microorganisms · 2025Review
- Risk of hepatocellular carcinoma in people with HIV in the United States, 2001-2019.Journal of the National Cancer Institute · 2024Article
- Research progress on the mechanism of exosome-mediated virus infection.Frontiers in cellular and infection microbiology · 2024Review
- Hepatocellular carcinoma presentation and prognosis among Nigerian adults with and without HIV.PloS one · 2023Observational
- Incidence and mortality of non-AIDS-defining cancers among people living with HIV: A systematic review and meta-analysis.EClinicalMedicine · 2022Article
- A simple CD4+ T cells to FIB-4 ratio for evaluating prognosis of BCLC-B hepatocellular carcinoma: a retrospective cohort study.BMC cancer · 2022Article
- Loco-Regional Treatments for Hepatocellular Carcinoma in People Living with HIV.Infectious disease reports · 2022Review
- Current impact of viral hepatitis on liver cancer development: The challenge remains.World journal of gastroenterology · 2021Review
- Brief Report: Accuracy of FIB-4 for Cirrhosis in People Living With HIV and Hepatocellular Carcinoma.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Chronic Hepatitis B and HIV Coinfection: A Continuing Challenge in the Era of Antiretroviral Therapy.Current hepatology reports · 2020Article
- NASH in HIV.Current HIV/AIDS reports · 2020Review
- HIV RNA, CD4+ Percentage, and Risk of Hepatocellular Carcinoma by Cirrhosis Status.Journal of the National Cancer Institute · 2020Article
- Screening for Hepatocellular Carcinoma in HIV-Infected Patients: Current Evidence and Controversies.Current HIV/AIDS reports · 2020Review
- Etiology of hepatocellular carcinoma in West Africa, a case-control study.International journal of cancer · 2018Article
- Cancer screening in women living with HIV infection.Women's health (London, England) · 2017Article
- Trends in Malignancies among Korean Patients Infected with Human Immunodeficiency Virus in the Highly Active Antiretroviral Therapy Era.Journal of Korean medical science · 2017Article
- Management of hepatitis B in special populations.Best practice & research. Clinical gastroenterology · 2017Review
- Evolving epidemiology of HIV-associated malignancies.Current opinion in HIV and AIDS · 2017Review
- Hepatocellular carcinoma in patients with HIV.Current opinion in HIV and AIDS · 2017Review
- Identification of the transcripts associated with spontaneous HCV clearance in individuals co-infected with HIV and HCV.BMC infectious diseases · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHepatocellular carcinoma (HCC) is a concern among individuals with human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS).
methodsThe authors analyzed population-based registry linkage data from the US HIV/AIDS Cancer Match Study (1980-2009) to examine the risk and trends of HCC among individuals with AIDS. Standardized incidence ratios (SIRs) were used to measure HCC risk relative to the general population, and Poisson regression was used to calculate incidence rate ratios (RR) comparing incidence among individuals with AIDS. People with AIDS were categorized according to their HIV risk group into high and low hepatitis C virus (HCV) prevalence groups based on their HIV transmission risk category.
resultsAmong 615,150 individuals with AIDS, HCC risk was elevated almost 4 times compared with the risk in the general population (N = 366; SIR, 3.8; 95% confidence interval, 3.5-4.3). Although HCC incidence increased steadily across calendar periods (P(trend) < .0001; adjusted for sex and age), the excess risk in individuals with AIDS compared with the general population remained somewhat constant (SIRs range, 3.5-3.9) between the monotherapy/dual therapy era (1990-1995) and the recent highly active antiretroviral therapy era (2001-2009). In a multivariate model adjusting for sex, race/ethnicity, and attained calendar period, HCC incidence increased with advancing age (P(trend) < .0001) and was associated with HIV risk groups with a known higher prevalence of HCV (adjusted RR, 2.2; 95% confidence interval, 1.8-2.8).
conclusionsHCC incidence in individuals with AIDS has increased over time despite improved HIV treatment regimens, likely reflecting prolonged survival with chronic liver disease. The high incidence in older adults suggests that this cancer will increase in importance with aging of the HIV-infected population.
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