ArticleHuman molecular genetics2012
Replication-timing boundaries facilitate cell-type and species-specific regulation of a rearranged human chromosome in mouse.
Article in Human molecular genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Control of DNA replication timing in the 3D genome.Nature reviews. Molecular cell biology · 2019Review
- Genome-wide stability of the DNA replication program in single mammalian cells.Nature genetics · 2019Article
- Article
- A changing paradigm of transcriptional memory propagation through mitosis.Nature reviews. Molecular cell biology · 2019Review
- Topokaryotyping demonstrates single cell variability and stress dependent variations in nuclear envelope associated domains.Nucleic acids research · 2018Article
- Integrative detection and analysis of structural variation in cancer genomes.Nature genetics · 2018Article
- Germline DNA replication timing shapes mammalian genome composition.Nucleic acids research · 2018Article
- Transient reduction of DNA methylation at the onset of meiosis in male mice.Epigenetics & chromatin · 2018Article
- Genome-Wide Analysis of the Arabidopsis Replication Timing Program.Plant physiology · 2018Article
- Bacterial artificial chromosomes establish replication timing and sub-nuclear compartment de novo as extra-chromosomal vectors.Nucleic acids research · 2018Article
- The impact of replication stress on replication dynamics and DNA damage in vertebrate cells.Nature reviews. Genetics · 2017Review
- Article
- Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction: insight into chromatin folding by polymer modelling.PLoS computational biology · 2014Article
- Article
- Single cell segmental aneuploidy detection is compromised by S phase.Molecular cytogenetics · 2014Article
- Murine esBAF chromatin remodeling complex subunits BAF250a and Brg1 are necessary to maintain and reprogram pluripotency-specific replication timing of select replication domains.Epigenetics & chromatin · 2013Article
- Genomic basis of aromatase excess syndrome: recombination- and replication-mediated rearrangements leading to CYP19A1 overexpression.The Journal of clinical endocrinology and metabolism · 2013Article
- The replication domain model: regulating replicon firing in the context of large-scale chromosome architecture.Journal of molecular biology · 2013Review
- Developmental control of replication timing defines a new breed of chromosomal domains with a novel mechanism of chromatin unfolding.Nucleus (Austin, Tex.)Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
In multicellular organisms, developmental changes to replication timing occur in 400-800 kb domains across half the genome. While examples of epigenetic control of replication timing have been described, a role for DNA sequence in mammalian replication-timing regulation has not been substantiated. To assess the role of DNA sequences in directing developmental changes to replication timing, we profiled replication timing in mice carrying a genetically rearranged Human Chromosome 21 (Hsa21). In two distinct mouse cell types, Hsa21 sequences maintained human-specific replication timing, except at points of Hsa21 rearrangement. Changes in replication timing at rearrangements extended up to 900 kb and consistently reconciled with the wild-type replication pattern at developmental boundaries of replication-timing domains. Our results are consistent with DNA sequence-driven regulation of Hsa21 replication timing during development and provide evidence that mammalian chromosomes consist of multiple independent units of replication-timing regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.