ArticleDigestive diseases and sciences2012
Fecal M2-PK in children with Crohn's disease: a preliminary report.
Article in Digestive diseases and sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Pyruvate kinase M2 modulates Japanese encephalitis virus replication in neuronal cells.The Journal of general virology · 2025Article
- Research progress on the role of PKM2 in the immune response.Frontiers in immunology · 2022Review
- Lactate modulation of immune responses in inflammatory versus tumour microenvironments.Nature reviews. Immunology · 2021Review
- Novel Biomarkers and the Future Potential of Biomarkers in Inflammatory Bowel Disease.Mediators of inflammation · 2017Review
- Pyruvate Kinase M2: A Potential Target for Regulating Inflammation.Frontiers in immunology · 2016Review
- Pyruvate kinase M2 regulates apoptosis of intestinal epithelial cells in Crohn's disease.Digestive diseases and sciences · 2015Article
- Comparison of fecal pyruvate kinase isoform M2 and calprotectin in acute diarrhea in hospitalized children.Scientific reports · 2014Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsAlthough active inflammatory changes in chronic Crohn's disease (CD) can be detected with serum inflammatory markers, these have low specificity and sensitivity. Stool markers of inflammation, such as M2-pyruvate kinase (M2-PK), permit more direct assessment of mucosal inflammation. The aim of this study was to assess levels of M2-PK in children with active CD and to compare to levels in healthy control children.
methodsFecal levels of M2-PK were measured by immunoassay using stored stool samples from children with untreated (active) CD and healthy control children. Correlations between M2-PK levels and disease activity scores and serum inflammatory markers were performed. Comparison was also made between M2PK and a second fecal inflammatory marker, S100A12.
resultsMean fecal M2-PK levels were higher in the 17 patients with active CD than in the 21 healthy controls (p = 0.0007). M2-PK levels did not correlate with disease activity scores or serum inflammatory markers. There was a trend for children with ileocolonic disease to have higher levels of M2-PK in their stool compared to those with colonic disease or isolated ileal disease. Fecal M2PK did not correlate with fecal S100A12 in children with active CD.
conclusionFecal M2-PK is increased in children with active CD, indicating that this marker may be a useful non-invasive marker for gut inflammation. Further studies of M2PK are required in additional settings with larger cohorts of children with CD and with comparison to other stool markers.
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