ArticleThe journal of physiological sciences : JPS2012
The role of central 5-HT(2C) and NMDA receptors on LPS-induced feeding behavior in chickens.
Article in The journal of physiological sciences : JPS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 18 citations in OpenAlex.
- Central and Peripheral Effects of Lipopolysaccharide on Food Choice and Macronutrient Selection in Meat-Type Chick.Archives of Razi Institute · 2023Article
- Biomolecules Triggering Altered Food Intake during Pathogenic Challenge in Chicks.The journal of poultry science · 2023Review
- Dopamine-induced hypophagia is mediated by D1 and 5HT-2c receptors in chicken.Veterinary research communications · 2014Article
- The role of glutamatergic and GABAergic systems on serotonin- induced feeding behavior in chicken.Veterinary research communications · 2013Article
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Authors and funding
4 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In mammals, LPS regulate feeding primarily through the 5-HT(1A) and 5-HT(2c) receptors within the brain. However, the central effect of 5-HT(1A) and 5-HT(2c) on LPS-induced feeding behavior has not been studied in non-mammalian species. Also, the role of glutamatergic system in LPS-induced anorexia has never been examined in either mammalian or non-mammalian species. Therefore, in this study, we examined the role of serotonergic and glutamatergic systems on LPS-induced anorexia in chickens. Food intake was measured in chickens after centrally administered lipopolysaccharide (LPS) (20 ng) (0 h), followed by intracerebroventricular (ICV) injection of the 5-HT(1A) autoreceptor agonist (8-OH-DPAT, 61 nmol), 5-HT(2c) receptor antagonist (SB 242084, 30 nm), and NMDA receptor antagonist (DL-AP5, 5 nm) at the onset of anorexia (4 h). In the following experiments, we used DL-AP5 before 5-HT (10 μg) and SB242084 before glutamate (300 nm) for evaluation of the interaction between 5-HTergic and glutamatergic systems on food intake. The results of this study showed that SB 242084 and DL-AP5 significantly attenuated food intake reduction caused by LPS (P < 0.05) but 8-OH-DPAT had no effect. In addition, 5-HT-induced anorexia was significantly attenuated by DL-AP5 pretreatment (P < 0.05), while SB 242084 had no effect on glutamate-induced hypophagia. These results indicated that 5-HT and glutamate (via 5-HT(2c) and NMDA receptor, respectively) dependently regulate LPS-induced hypophagia in chickens.
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