ReviewExperimental gerontology2012
Genetics of subcortical vascular dementia.
Review in Experimental gerontology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Unwinding the Neurovascular Unit: The Vascular Extracellular Matrix and Mechanochemical Collagen Functionalization in Vascular Dementia.International journal of molecular sciences · 2026Review
- Research and development prospects of TRIM65.Journal of cancer research and clinical oncology · 2025Review
- Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers.GeroScience · 2025Article
- The Magic and Mystery of TRIM65 in Diseases.Current medicinal chemistry · 2025Review
- Blood pressure variability, central autonomic network dysfunction and cerebral small vessel disease in APOE4 carriers.medRxiv : the preprint server for health sciences · 2023Article
- The Emerging Roles of Tripartite Motif Proteins (TRIMs) in Acute Lung Injury.Journal of immunology research · 2021Review
- Prostaglandin EFrontiers in aging neuroscience · 2021Article
- HDAC inhibitor protects chronic cerebral hypoperfusion and oxygen-glucose deprivation injuries via H3K14 and H4K5 acetylation-mediated BDNF expression.Journal of cellular and molecular medicine · 2020Article
- TRIM65 E3 ligase targets VCAM-1 degradation to limit LPS-induced lung inflammation.Journal of molecular cell biology · 2020Article
- Ubiquitin ligase TRIM65 promotes colorectal cancer metastasis by targeting ARHGAP35 for protein degradation.Oncogene · 2019Article
- Stroke Risk and Vascular Dementia in South Asians.Current atherosclerosis reports · 2018Review
- Genetic evidence for common pathways in human age-related diseases.Aging cell · 2015Article
- Genetics and underlying pathology of dementia.Neuropsychology review · 2015Review
- Microvascular pathology and morphometrics of sporadic and hereditary small vessel diseases of the brain.Brain pathology (Zurich, Switzerland) · 2014Review
- Trim65: a cofactor for regulation of the microRNA pathway.RNA biology · 2014Article
- Comparison of medial temporal measures between Binswanger's disease and Alzheimer's disease.PloS one · 2014Article
- The pathobiology of vascular dementia.Neuron · 2013Review
- Impact of body mass index on neuronal fiber bundle lengths among healthy older adults.Brain imaging and behavior · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subcortical vascular dementia or cerebral small vessel disease is a common cause of disability in the elderly. On magnetic resonance imaging the disease is manifested as white matter lesions, lacunes and microbleeds. Its etiology is complex, with age and hypertension as established risk factors. The heritability of white matter lesions is constantly high over different populations. Linkage studies identified several loci for these lesions however no genes responsible for the linkage signals had been identified so far. Results from genetic association studies using the candidate gene approach support the role of APOE, the renin-angiotensin system, as well as the Notch3 signaling pathway in the development of subcortical vascular dementia. The recent genomegenome wide association study on white matter lesions identified a novel locus on chromosome 17q25 harboring several genes such as TRIM65 and TRIM47 which pinpoints to possible novel mechanisms leading to these lesions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.