ArticleBiophysical journal2012
Locomotion control of Caenorhabditis elegans through confinement.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Mechanosensory encoding of surface mechanics optimizes locomotion.Nature communications · 2026Article
- Behavioral adjustment of C. elegans to mechanosensory loss requires intact mechanosensory neurons.PLoS biology · 2024Article
- A Compact Imaging Platform for ConductingLife (Basel, Switzerland) · 2023Article
- A Neuromechanical Model of Multiple Network Rhythmic Pattern Generators for Forward Locomotion inFrontiers in computational neuroscience · 2021Article
- Proprioception in Action: A Matter of Ecological and Social Interaction.Frontiers in psychology · 2020Article
- Swim exercise inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Quantifying the mechanics of locomotion of the schistosome pathogen with respect to changes in its physical environment.Journal of the Royal Society, Interface · 2019Article
- Signatures of proprioceptive control inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Three-dimensional simulation of thePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Potential role of a ventral nerve cord central pattern generator in forward and backward locomotion inNetwork neuroscience (Cambridge, Mass.) · 2018Article
- Determining the biomechanics of touch sensation in C. elegans.Scientific reports · 2017Article
- Food responsiveness regulates episodic behavioral states inJournal of neurophysiology · 2017Article
- CeleST: computer vision software for quantitative analysis of C. elegans swim behavior reveals novel features of locomotion.PLoS computational biology · 2014Article
- Neurobiology ofBioscience · 2014Article
- The co-constitution of the self and the world: action and proprioceptive coupling.Frontiers in psychology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The model organism Caenorhabditis elegans shows two distinct locomotion patterns in laboratory situations: it swims in low viscosity liquids and it crawls on the surface of an agar gel. This provides a unique opportunity to discern the respective roles of mechanosensation (perception and proprioception) and mechanics in the regulation of locomotion and in the gait selection. Using an original device, we present what to our knowledge are new experiments where the confinement of a worm between a glass plate and a soft agar gel is controlled while recording the worm's motion. We observed that the worm continuously varied its locomotion characteristics from free swimming to slow crawling with increasing confinement so that it was not possible to discriminate between two distinct intrinsic gaits. This unicity of the gait is also proved by the fact that wild-type worms immediately adapted their motion when the imposed confinement was changed with time. We then studied locomotory deficient mutants that also exhibited one single gait and showed that the light touch response was needed for the undulation propagation and that the ciliated sensory neurons participated in the joint selection of motion period and undulation-wave velocity. Our results reveal that the control of maximum curvature, at a sensory or mechanical level, is a key ingredient of the locomotion regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.