ArticleBiophysical journal2012
Mismatch in mechanical and adhesive properties induces pulsating cancer cell migration in epithelial monolayer.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 104 citations in OpenAlex.
- Methods to analyze cell migration data: fundamentals and practical guidelines.Nature methods · 2026Review
- Article
- Single-Cell Fluidic Force Spectroscopy Reveals Dynamic Mechanical Fingerprints of Malignancy in Breast Cancer.ACS applied materials & interfaces · 2024Article
- E-Cadherin Induces Serine Synthesis to Support Progression and Metastasis of Breast Cancer.Cancer research · 2024Article
- Local, Sustained, and Targeted Co-Delivery of MEK Inhibitor and Doxorubicin Inhibits Tumor Progression in E-Cadherin-Positive Breast Cancer.Pharmaceutics · 2024Article
- E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer.Oncogene · 2024Article
- Matrix confinement modulates 3D spheroid sorting and burst-like collective migration.Acta biomaterialia · 2024Article
- Cell adhesion molecule BVES functions as a suppressor of tumor cells extrusion in hepatocellular carcinoma metastasis.Cell communication and signaling : CCS · 2022Article
- Marangoni effect and cell spreading.European biophysics journal : EBJ · 2022Review
- Single-cell tracking reveals super-spreading brain cancer cells with high persistence.Biochemistry and biophysics reports · 2021Article
- A designer cell culture insert with a nanofibrous membrane toward engineering an epithelial tissue model validated by cellular nanomechanics.Nanoscale advances · 2021Article
- Article
- Biophysical interactions between components of the tumor microenvironment promote metastasis.Biophysical reviews · 2021Review
- The influence of cell elastic modulus on inertial positions in Poiseuille microflows.Biophysical journal · 2021Article
- Particle tracking microrheology of cancer cells in living subjects.Materials today (Kidlington, England) · 2020Article
- The mechanical responses of advecting cells in confined flow.Biomicrofluidics · 2020Review
- The in vitro inertial positions and viability of cells in suspension under different in vivo flow conditions.Scientific reports · 2020Article
- Single-cell morphology encodes metastatic potential.Science advances · 2020Article
- Dynamics phenotyping across length and time scales in collective cell migration.Seminars in cell & developmental biology · 2019Review
- Sharp interface model for elastic motile cells.The European physical journal. E, Soft matter · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The mechanical and adhesive properties of cancer cells significantly change during tumor progression. Here we assess the functional consequences of mismatched stiffness and adhesive properties between neighboring normal cells on cancer cell migration in an epithelial-like cell monolayer. Using an in vitro coculture system and live-cell imaging, we find that the speed of single, mechanically soft breast carcinoma cells is dramatically enhanced by surrounding stiff nontransformed cells compared with single cells or a monolayer of carcinoma cells. Soft tumor cells undergo a mode of pulsating migration that is distinct from conventional mesenchymal and amoeboid migration, whereby long-lived episodes of slow, random migration are interlaced with short-lived episodes of extremely fast, directed migration, whereas the surrounding stiff cells show little net migration. This bursty migration is induced by the intermittent, myosin II-mediated deformation of the soft nucleus of the cancer cell, which is induced by the transient crowding of the stiff nuclei of the surrounding nontransformed cells, whose movements depend directly on the cadherin-mediated mismatched adhesion between normal and cancer cells as well as α-catenin-based intercellular adhesion of the normal cells. These results suggest that a mechanical and adhesive mismatch between transformed and nontransformed cells in a cell monolayer can trigger enhanced pulsating migration. These results shed light on the role of stiff epithelial cells that neighbor individual cancer cells in early steps of cancer dissemination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.