ArticleNature communications2012
Chloroplast-mediated activation of plant immune signalling in Arabidopsis.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 190 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
190 citing papers in PubMed, 418 citations in OpenAlex.
- Molecular Cytogenetic and Transcriptome Characterization of a Novel Wheat-Plants (Basel, Switzerland) · 2026Article
- Review
- SIB1-SEC23A undergo ER to chloroplast relocalization to mediate immunity in Arabidopsis thaliana.Journal of integrative plant biology · 2026Article
- PLASTID ENVELOPE ION CHANNELS (PEC1/2) link CaProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Integrated Functional Characterization of Hemileia vastatrix Effector Candidates Reveals Coordinated Immune Suppression, Sequential Deployment and Compartment-Specific Targeting.Molecular plant pathology · 2026Article
- Synthetic ion channel inhibitors enhance plant drought tolerance.Nature communications · 2026Article
- Chloroplasts and Plant Sustainability: Key Roles and Emerging Insights.International journal of molecular sciences · 2026Review
- Singlet Oxygen Generation and Signaling in Higher Plants.International journal of molecular sciences · 2026Review
- Viral proteins as discovery tools for cell biology: The case of the geminivirus-encoded C4.PLoS pathogens · 2026Article
- Calcium signaling in soybean-virus interactions: emerging roles of calcium sensors in antiviral and environmental stress responses.Frontiers in plant science · 2026Review
- Pathogen effector tactics to suppress plant endomembrane system.Frontiers in plant science · 2026Review
- Calcium-sensing receptor AcCaS regulates chloroplast immunity in kiwifruit by competitively binding with CaHorticulture research · 2025Article
- Functional evaluation of pathogenesis-related protein-1 (PR1) genes in mung bean (Vigna radiata) response to Pythium myriotylum.BMC genomics · 2025Article
- Membrane contact sites between chloroplasts and the pathogen interface underpin plant focal immune responses.The Plant cell · 2025Article
- Histone ZmH2B regulates resistance to the Southern corn leaf blight pathogen Bipolaris maydis in maize.BMC plant biology · 2025Article
- The important role of chloroplasts in plant immunity.Plant communications · 2025Review
- Inter-Organellar CaCells · 2025Review
- A fungal effector promotes infection via stabilizing a negative regulatory factor of chloroplast immunity.Nature communications · 2025Article
- Filamentous Temperature-Sensitive Z Protein J175 Regulates Maize Chloroplasts' and Amyloplasts' Division and Development.Plants (Basel, Switzerland) · 2025Article
- Integrative multi-transcriptomic analysis uncovers core genes and potential defense mechanisms in rice-Magnoporthe oryzae interaction.Plant cell reports · 2025Article
130 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chloroplasts have a critical role in plant immunity as a site for the production for salicylic acid and jasmonic acid, important mediators of plant immunity. However, the molecular link between chloroplasts and the cytoplasmic-nuclear immune system remains largely unknown. Here we show that pathogen-associated molecular pattern (PAMP) signals are quickly relayed to chloroplasts and evoke specific Ca(2+) signatures in the stroma. We further demonstrate that a chloroplast-localized protein, named calcium-sensing receptor (CAS), is involved in stromal Ca(2+) transients and responsible for both PAMP-induced basal resistance and R gene-mediated hypersensitive cell death. CAS acts upstream of salicylic acid accumulation. Transcriptome analysis demonstrates that CAS is involved in PAMP-induced expression of defence genes and suppression of chloroplast gene expression possibly through (1)O(2)-mediated retrograde signalling, allowing chloroplast-mediated transcriptional reprogramming during plant immune responses. The present study reveals a previously unknown chloroplast-mediated signalling pathway linking chloroplasts to cytoplasmic-nuclear immune responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.