Evidence map›Paper›PMID 22735449›Full record

ArticleNature communications2012

Microscopic magnetic stimulation of neural tissue.

Giorgio Bonmassar, Seung Woo Lee, Daniel K Freeman, Miloslav Polasek, Shelley I Fried, John T Gale

Open access · hybridAbstract read
In one paragraph

Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 184 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. Article
  7. Microfabrication Technologies for Nanoinvasive and High-Resolution Magnetic Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Advances in the Regulation of Neural Function by Infrared Light.International journal of molecular sciences · 2024
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Bioengineering strategies for restoring vision.Nature biomedical engineering · 2023
    Review
  18. Improving focality and consistency in micromagnetic stimulation.Frontiers in computational neuroscience · 2023
    Article
  19. Review
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Giorgio BonmassarAthinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Seung Woo Lee
Daniel K Freeman
Miloslav Polasek
Shelley I Fried
John T Gale
Massachusetts General Hospital · USHarvard University · USThe Neurological Institute · USVA Boston Healthcare System · US

Funding

ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A · 1999 to 2011
$16.4M
Dynamic Inverse Solutions for Multimodal ImagingR01EB006385 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A · 2007 to 2011
$6.7M
The mechanism by which electric stimulation activates retinal neuronsR01EY019967 · NEI · MASSACHUSETTS GENERAL HOSPITAL · PI FRIED, SHELLEY · 2010 to 2014
$1.9M
HRS targeting of ON and OFF ganglion cellsR01EY023651 · NEI · MASSACHUSETTS GENERAL HOSPITAL · PI FRIED, SHELLEY · 2013 to 2016
$1.4M
Intracranial Micro Magnetic Stimulation of the Frontal Eye Field in MonkeysR21EY020961 · NEI · MASSACHUSETTS GENERAL HOSPITAL · PI BONMASSAR, GIORGIO, VANDUFFEL, WIM JAN · 2010 to 2010
$228k
Informing the Sub-Retinal Approach to Stimualation of the Retina.I01RX000350 · VA · VA BOSTON HEALTH CARE SYSTEM · PI FRIED, SHELLEY · 2011 to 2014
–
NCRR NIH HHS P41 RR014075NCRR NIH HHS P41-RR14075NEI NIH HHS 1R21EY020961-01NEI NIH HHS R01 EY019967NEI NIH HHS R01EY019967NEI NIH HHS R01 EY023651NEI NIH HHS R21 EY020961NIBIB NIH HHS R01 EB006385NIBIB NIH HHS R01EB006385RRD VA I01 RX000350
6 · The paper itself

Abstract

Electrical stimulation is currently used to treat a wide range of cardiovascular, sensory and neurological diseases. Despite its success, there are significant limitations to its application, including incompatibility with magnetic resonance imaging, limited control of electric fields and decreased performance associated with tissue inflammation. Magnetic stimulation overcomes these limitations but existing devices (that is, transcranial magnetic stimulation) are large, reducing their translation to chronic applications. In addition, existing devices are not effective for deeper, sub-cortical targets. Here we demonstrate that sub-millimeter coils can activate neuronal tissue. Interestingly, the results of both modelling and physiological experiments suggest that different spatial orientations of the coils relative to the neuronal tissue can be used to generate specific neural responses. These results raise the possibility that micro-magnetic stimulation coils, small enough to be implanted within the brain parenchyma, may prove to be an effective alternative to existing stimulation devices.

Indexed as

Electric StimulationMagneticsHumansMagnetic Field TherapyModels, TheoreticalNeuronsTranscranial Magnetic Stimulation

Identifiers

PMID22735449
PMCPMC3621430
OpenAlexW4237004966

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.