ArticleNature communications2012
Emergence of stable polymorphisms driven by evolutionary games between mutants.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Local negative frequency dependence can decrease global coexistence in fragmented populations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Empirical evidence of resource dependent evolution of payoff matrices in Saccharomyces cerevisiae populations.Journal of evolutionary biology · 2025Article
- Competition for resources can reshape the evolutionary properties of spatial structure.PLoS computational biology · 2024Article
- Competition for resources can reshape the evolutionary properties of spatial structure.bioRxiv : the preprint server for biology · 2024Article
- The Contribution of Evolutionary Game Theory to Understanding and Treating Cancer.Dynamic games and applications · 2022Review
- Why is cyclic dominance so rare?eLife · 2020Article
- Evolutionary games with environmental feedbacks.Nature communications · 2020Article
- Evolution of joint cooperation under phenotypic variations.Scientific reports · 2018Article
- Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity.Nature communications · 2017Article
- Article
- The mathematics of cancer: integrating quantitative models.Nature reviews. Cancer · 2015Review
- Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants.Viruses · 2015Observational
- Stochastic game dynamics under demographic fluctuations.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Collapse of cooperation in evolving games.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Fixation in finite populations evolving in fluctuating environments.Journal of the Royal Society, Interface · 2014Article
- Extrapolating weak selection in evolutionary games.PLoS computational biology · 2013Article
- The impact of random frequency-dependent mutations on the average population fitness.BMC evolutionary biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Under neutrality, polymorphisms are maintained through the balance between mutation and drift. Under selection, a variety of mechanisms may be involved in the maintenance of polymorphisms, for example, sexual selection or host-parasite coevolution on the population level or heterozygote advantage in diploid individuals. Here we address the emergence of polymorphisms in a population of interacting haploid individuals. In our model, each mutation generates a new evolutionary game characterized by a payoff matrix with an additional row and an additional column. Hence, in general, the fitness of new mutations is frequency-dependent rather than constant. This dynamical process is distinct from the sequential fixation of advantageous traits and naturally leads to the emergence of polymorphisms under selection. It causes substantially higher diversity than observed under the established models of neutral or frequency-independent selection. Our framework allows for the coexistence of an arbitrary number of types, but predicts an intermediate average diversity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.