ArticleExpert review of anti-infective therapy2012
Cryptococcus gattii as an important fungal pathogen of western North America.
Article in Expert review of anti-infective therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Dose Optimization of Fluconazole After Initial Treatment Failure in Pulmonary Cryptococcosis in an Obese Patient with Type 2 Diabetes and Cirrhosis: A Case Report.Infection and drug resistance · 2024Article
- The Cryptococcus gattii species complex: Unique pathogenic yeasts with understudied virulence mechanisms.PLoS neglected tropical diseases · 2022Review
- Article
- The aetiology and clinical characteristics of cryptococcal infections in Far North Queensland, tropical Australia.PloS one · 2022Article
- Ophthalmic manifestations ofInternational journal of ophthalmology · 2022Article
- Transudative pleural effusion as an initial presentation of a disseminated cryptococcosis infection in a HIV-negative patient with cirrhosis.Medical mycology case reports · 2021Article
- Pulmonary cryptococcosis coexisting with central type lung cancer in an immuocompetent patient: a case report and literature review.BMC pulmonary medicine · 2020Review
- Cryptococcal meningoencephalitis in an IgGBMC neurology · 2020Article
- Cryptococcus gattii molecular type VGII infection associated with lung disease in a goat.BMC veterinary research · 2017Article
- Pleural effusion as the initial clinical presentation in disseminated cryptococcosis and fungaemia: an unusual manifestation and a literature review.BMC infectious diseases · 2015Review
- 'Division of labour' in response to host oxidative burst drives a fatal Cryptococcus gattii outbreak.Nature communications · 2014Article
- Cryptococcus gattii infections.Clinical microbiology reviews · 2014Review
- A multiplex real-time PCR assay for identification of Pneumocystis jirovecii, Histoplasma capsulatum, and Cryptococcus neoformans/Cryptococcus gattii in samples from AIDS patients with opportunistic pneumonia.Journal of clinical microbiology · 2014Article
- Transmission of Hypervirulence traits via sexual reproduction within and between lineages of the human fungal pathogen cryptococcus gattii.PLoS genetics · 2013Article
- Rare Cryptococus gattii infection in an immunocompetent dairy goat following a cesarean section.Medical mycology case reports · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Cryptococcus gattii, a pathogenic fungus historically appreciated to be endemic to tropical regions, was recognized to emerge in a more temperate zone of North America in the 1990s. Early reports focused on an outbreak that was first apparent on Vancouver Island (BC, Canada), involving both the veterinary and human population. More recently, it has been recognized that this organism is endemic to a wider geography in western North America, with recognized disease caused by unique molecular subtypes in both healthy and immunosuppressed human hosts and a variety of domestic and wild animals. A number of cases of disease caused by C. gattii isolates that are unrelated to the Vancouver Island-Pacific Northwest outbreak strains have also been recognized in different parts of the USA. As microbiology laboratories have historically not identified these organisms to the species level, our current understanding of the scope of this infection is probably an underestimate. Ongoing public health epidemiologic efforts will be facilitated by increased attention towards culture-confirmed diagnosis and species identification in clinical microbiology laboratories. Early experience presents a strong rationale for increasing diagnostic attention, with multiple clinical features that are unique to this infection, including variability in antifungal susceptibilities and a heightened need for aggressive management of inflammatory responses. Larger prospective studies to evaluate and optimize clinical management are needed.
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