ArticleJournal of applied microbiology2012
Examination of nanoparticle inactivation of Campylobacter jejuni biofilms using infrared and Raman spectroscopies.
Article in Journal of applied microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- ZnO Nanocrystals InhibitInternational journal of nanomedicine · 2026Article
- Evaluation of physical and chemical isolation methods to extract and purifyFrontiers in microbiology · 2024Article
- Nanotechnology in Food and Plant Science: Challenges and Future Prospects.Plants (Basel, Switzerland) · 2023Review
- Campylobacter jejuni Antimicrobial Resistance Profiles and Mechanisms Determined Using a Raman Spectroscopy-Based Metabolomic Approach.Applied and environmental microbiology · 2021Article
- Behavior and Mechanism of Cesium Biosorption from Aqueous Solution by LivingMicroorganisms · 2020Article
- Soil pH effects on the interactions between dissolved zinc, non-nano- and nano-ZnO with soil bacterial communities.Environmental science and pollution research international · 2016Article
- Biofilm spatial organization by the emerging pathogen Campylobacter jejuni: comparison between NCTC 11168 and 81-176 strains under microaerobic and oxygen-enriched conditions.Frontiers in microbiology · 2015Article
- Investigating the responses of Cronobacter sakazakii to garlic-drived organosulfur compounds: a systematic study of pathogenic-bacterium injury by use of high-throughput whole-transcriptome sequencing and confocal micro-raman spectroscopy.Applied and environmental microbiology · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
aimsTo investigate inactivation effect and mechanism of zinc oxide nanoparticles (ZnO NPs) activity against Campylobacter jejuni biofilms. METHODS AND
resultsZnO NPs with concentrations of 0, 0·6, 1·2 and 6 mmol l(-1) were employed in antimicrobial tests against Camp. jejuni planktonic cells and biofilms. Campylobacter jejuni sessile cells in biofilms were more resistant to a low concentration of ZnO NPs when compared to planktonic cells. The ZnO NPs penetrated the extracellular polymeric substance (EPS) without damage to the EPS and directly interacted with the sessile bacterial cells, as determined using infrared spectroscopy and scanning electron microscopy. Raman spectroscopy shows alterations in quinone structures and damage to nucleic acids following Camp. jejuni treatment with ZnO NPs. The mechanism of DNA damage is most likely due to the generation of reactive oxygen species (ROS). Spectroscopic-based partial least squares regression (PLSR) models could predict the number of surviving sessile cell numbers within a bacterial biofilm (≥log 4 CFU, root mean square error of estimation <0·36) from Fourier transform infrared (FT-IR) spectral measurements.
conclusionsZnO NPs were found to have antimicrobial activity against Camp. jejuni biofilms. ZnO NPs penetrated the biofilm EPS within 1 h without damaging it and interacted directly with sessile cells in biofilms. Alterations in the DNA/RNA bases, which are owing to the generation of ROS, appear to result in Camp. jejuni cell death. SIGNIFICANCE AND IMPACT OF THE STUDY: ZnO NPs may offer a realistic strategy to eliminate Camp. jejuni biofilms in the environment.
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