Evidence map›Paper›PMID 22734727›Full record

ArticleJournal of biomedical optics2012

Investigation of the hyper-reflective inner/outer segment band in optical coherence tomography of living frog retina.

Rong-Wen Lu, Christine A Curcio, Youwen Zhang, Qiu-Xiang Zhang, Steven J Pittler, Dusanka Deretic, Xin-Cheng Yao

Abstract readLetter
In one paragraph

Article in Journal of biomedical optics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rong-Wen Lu
Christine A Curcio
Youwen Zhang
Qiu-Xiang Zhang
Steven J Pittler
Dusanka Deretic
Xin-Cheng Yao

Funding

Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LAWRENCE C SINCICH · 1985 to 2026
$16.9M
Rhodopsin Trafficking & Photoreceptor Membrane RenewalR01EY012421 · NEI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI DERETIC, DUSANKA DANIELLE · 1999 to 2023
$7.2M
QUANTITATIVE ANAYLSIS OF AGING RETINAR01EY006109 · NEI · UNIVERSITY OF WASHINGTON · PI CURCIO, CHRISTINE A · 1986 to 2012
$3.5M
Analysis of retina rod photoreceptor GARP and cGMP-gated channelR01EY018143 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PITTLER, STEVEN J · 2008 to 2016
$2.9M
Multifocal Optical Coherence MicroscopeR21RR025788 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YAO, XINCHENG · 2009 to 2010
$517k
Angle-resolved polarization signal imaging of early receptor potentialR21EB012264 · NIBIB · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YAO, XINCHENG · 2011 to 2012
$381k
NCRR NIH HHS R21 RR025788NEI NIH HHS P30 EY003039NEI NIH HHS P30 EY03039NEI NIH HHS R01 EY006109NEI NIH HHS R01 EY012421NEI NIH HHS R01 EY018143NEI NIH HHS R01 EY06109NIBIB NIH HHS R21 EB012264
6 · The paper itself

Abstract

This study is to test anatomic correlates, including connecting cilium (CC) and inner segment (IS) ellipsoid, to the hyper-reflective band visualized by optical coherence tomography (OCT) and commonly attributed to the photoreceptor inner/outer segment (IS/OS) junction. A line-scan OCT (LS-OCT) was constructed to achieve sub-cellular resolution (lateral: ≈ 2 μm; axial: ≈ 4 μm) of excised living frog retinas. An electro-optic phase modulator was employed for rapid and vibration-free phase modulation. Comparison of normalized distance measurements between LS-OCT images and histological images revealed that the dominant source of the signal reported as the IS/OS OCT band actually originates from the IS.

Indexed as

AlgorithmsAnimalsElectrophysiologyEquipment DesignLightOptics and PhotonicsPhotoreceptor Cells, VertebrateRanidaeReproducibility of ResultsRetinaRetinal Photoreceptor Cell Outer SegmentSignal Processing, Computer-AssistedTomography, Optical Coherence

Identifiers

PMID22734727
PMCPMC3381034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.