ArticleNeurogastroenterology and motility2012
Platelet-activating factor and distinct chemokines are elevated in mucosal biopsies of erosive compared with non-erosive reflux disease patients and controls.
Article in Neurogastroenterology and motility, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Systemic inflammatory biomarkers in gastroesophageal reflux disease: current evidence and future perspectives.Frontiers in medicine · 2026Review
- Immune system and microbiome in the esophagus: implications for understanding inflammatory diseases.The FEBS journal · 2022Review
- Association between Dietary Habits and Fecal Microbiota Composition in Irritable Bowel Syndrome Patients: A Pilot Study.Nutrients · 2021Article
- The Risk of Acute Myocardial Infarction in Patients With Gastroesophageal Reflux Disease.Journal of neurogastroenterology and motility · 2020Article
- Exploration of the Esophageal Mucosal Barrier in Non-Erosive Reflux Disease.International journal of molecular sciences · 2017Article
- Prevalence of allergic rhinitis and asthma in patients with chronic rhinosinusitis and gastroesophageal reflux disease.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2016Article
- Biomarkers of Reflux Disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2016Review
- Article
- Eosinophilic esophagitis: New insights in pathogenesis and therapy.World journal of gastrointestinal pharmacology and therapeutics · 2016Review
- Article
- Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility.International journal of biological sciences · 2015Article
- Invariant natural killer T cells in children with eosinophilic esophagitis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Article
- Gastroesophageal reflux disease: Update on inflammation and symptom perception.World journal of gastroenterology · 2013Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundA distinction between symptomatic non-erosive reflux disease (NERD) and erosive esophagitis (EE) patients is supported by the presence of inflammatory response in the mucosa of EE patients, leading to a damage of mucosal integrity. To explore the underlying mechanism of this difference, we assessed inflammatory mediators in mucosal biopsies from EE and NERD patients and compared them with controls.
methodsNineteen NERD patients, 15 EE patients, and 16 healthy subjects underwent endoscopy after a 3-week washout from PPI or H(2) antagonists. Biopsies obtained from the distal esophagus were examined by quantitative real-time polymerase chain reaction (qPCR) and multiplex enzyme-linked immunosorbent assay for selected chemokines and lyso-PAF acetyltransferase (LysoPAF-AT), the enzyme responsible for production of platelet-activating factor (PAF). KEY
resultsExpression of LysoPAF-AT and multiple chemokines was significantly increased in mucosal biopsies derived from EE patients, when compared with NERD patients and healthy controls. Upregulated chemokines included interleukin 8, eotaxin-1, -2, and -3, macrophage inflammatory protein-1α (MIP-1α), and monocyte chemoattractant protein-1 (MCP-1). LysoPAF-AT and the chemokine profile in NERD patients were comparable with healthy controls. CONCLUSIONS & INFERENCES: Levels of selected cytokines and Lyso-PAF AT were significantly higher in the esophageal mucosa of EE patients compared with NERD and control patients. This difference may explain the distinct inflammatory response occurring in EE patients' mucosa. In contrast, as no significant differences existed between the levels of all mediators in NERD and control subjects, an inflammatory response does not appear to play a major role in the pathogenesis of the abnormalities found in NERD patients.
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Registered trials
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