ArticleJournal of the International Society of Sports Nutrition2012
A sportomics strategy to analyze the ability of arginine to modulate both ammonia and lymphocyte levels in blood after high-intensity exercise.
Article in Journal of the International Society of Sports Nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Metabolomics in Exercise and Sports: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- The effect of multi-ingredient intra- versus extra-cellular buffering supplementation combined with branched-chain amino acids and creatine on exercise-induced ammonia blood concentration and aerobic capacity in taekwondo athletes.Journal of the International Society of Sports Nutrition · 2021Trial
- Effect of Almond Supplementation on Non-Esterified Fatty Acid Values and Exercise Performance.Nutrients · 2020Trial
- Trial
- The endurance effort on a mechanical treadmill does not activate the complement system among trained young women.PloS one · 2026Article
- Effect of repeated sprint exercise on immunological responses in adult and adolescent athletes at different stages of biological maturation: a-quasi-experimental-trial.Scientific reports · 2025Article
- Determination of optimum intensity and duration of exercise based on the immune system response using a machine-learning model.Scientific reports · 2023Article
- Editorial: Metabolic response: nexus or nemesis for the understanding of sports nutrition and doping.Frontiers in nutrition · 2023Article
- Sportomics method to assess acute phase proteins in Olympic level athletes using dried blood spots and multiplex assay.Scientific reports · 2022Article
- Network Physiology of Exercise: Beyond Molecular and Omics Perspectives.Sports medicine - open · 2022Article
- Sportomics suggests that albuminuria is a sensitive biomarker of hydration in cross combat.Scientific reports · 2022Article
- The effects of acute and chronic oral l-arginine supplementation on exercise-induced ammonia accumulation and exercise performance in healthy young men: A randomised, double-blind, cross-over, placebo-controlled trial.Journal of exercise science and fitness · 2022Article
- Probiotic Strains Isolated from an Olympic Woman's Weightlifting Gold Medalist Increase Weight Loss and Exercise Performance in a Mouse Model.Nutrients · 2022Article
- Molecular Big Data in Sports Sciences: State-of-Art and Future Prospects of OMICS-Based Sports Sciences.Frontiers in molecular biosciences · 2021Review
- Hematological parameters in champion of Brazilian jiu-jitsu paradesport: Case study.Physiological reports · 2020Article
- Investigating the Cellular and Metabolic Responses of World-Class Canoeists Training: A Sportomics Approach.Nutrients · 2016Article
- Novel metabolic roles of L-arginine in body energy metabolism and possible clinical applications.The journal of nutrition, health & aging · 2014Article
- The effect of almond consumption on elements of endurance exercise performance in trained athletes.Journal of the International Society of Sports Nutrition · 2014Article
- Amino acid supplementation and impact on immune function in the context of exercise.Journal of the International Society of Sports Nutrition · 2014Article
- Metabolic responses to a 48-h ultra-marathon run in middle-aged male amateur runners.European journal of applied physiology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
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backgroundExercise is an excellent tool to study the interactions between metabolic stress and the immune system. Specifically, high-intensity exercises both produce transient hyperammonemia and influence the distribution of white blood cells. Carbohydrates and glutamine and arginine supplementation were previously shown to effectively modulate ammonia levels during exercise. In this study, we used a short-duration, high-intensity exercise together with a low carbohydrate diet to induce a hyperammonemia state and better understand how arginine influences both ammonemia and the distribution of leukocytes in the blood.
methodsBrazilian Jiu-Jitsu practitioners (men, n = 39) volunteered for this study. The subjects followed a low-carbohydrate diet for four days before the trials and received either arginine supplementation (100 mg·kg-1 of body mass·day-1) or a placebo. The intergroup statistical significance was calculated by a one-way analysis of variance, followed by Student's t-test. The data correlations were calculated using Pearson's test.
resultsIn the control group, ammonemia increased during matches at almost twice the rate of the arginine group (25 mmol·L-1·min-1 and 13 μmol·L-1·min-1, respectively). Exercise induced an increase in leukocytes of approximately 75%. An even greater difference was observed in the lymphocyte count, which increased 2.2-fold in the control group; this increase was partially prevented by arginine supplementation. The shape of the ammonemia curve suggests that arginine helps prevent increases in ammonia levels.
conclusionsThese data indicate that increases in lymphocytes and ammonia are simultaneously reduced by arginine supplementation. We propose that increased serum lymphocytes could be related to changes in ammonemia and ammonia metabolism.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.