Evidence map›Paper›PMID 22733974›Full record

ArticleEndocrinology2012

Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society.

R Thomas Zoeller, T R Brown, L L Doan, A C Gore, N E Skakkebaek, A M Soto, T J Woodruff, F S Vom Saal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 436 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
436citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

436 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Phthalate Exposures and Placental Health in Animal Models and Humans: A Systematic Review.Toxicological sciences : an official journal of the Society of Toxicology · 2022
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review

376 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

R Thomas ZoellerBiology Department, University of Massachusetts, 611 North Pleasant Street, Amherst, Massachusetts 01003, USA. tzoeller@bio.umass.edu
T R Brown
L L Doan
A C Gore
N E Skakkebaek
A M Soto
T J Woodruff
F S Vom Saal

Funding

Mechanisms of developmental toxicity of Bisphenol-AR01ES008314 · NIEHS · TUFTS UNIVERSITY BOSTON · PI SOTO, ANA · 1996 to 2016
$6.8M
PCB Disruption of Thyroid Hormone Action During DevelopmentR01ES010026 · NIEHS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ZOELLER, ROBERT THOMAS · 2000 to 2013
$3.8M
Project 2: Assessing the Effects on BPA Exposure on Early Human DevelopmentP20ES018135 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STOTLAND, NAOMI E · 2010 to 2012
$617k
PCB Disruption of Thyroid Hormone Action during DevelopmentR56ES010026 · NIEHS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ZOELLER, ROBERT THOMAS · 2007 to 2007
$387k
NICHD NIH HHS HD05574NIEHS NIH HHS ES01839NIEHS NIH HHS ES08314NIEHS NIH HHS ES10026NIEHS NIH HHS P20 ES018135NIEHS NIH HHS R01 ES008314NIEHS NIH HHS R01 ES010026NIEHS NIH HHS R56 ES010026
6 · The paper itself

Abstract

An endocrine-disrupting chemical (EDC) is an exogenous chemical, or mixture of chemicals, that can interfere with any aspect of hormone action. The potential for deleterious effects of EDC must be considered relative to the regulation of hormone synthesis, secretion, and actions and the variability in regulation of these events across the life cycle. The developmental age at which EDC exposures occur is a critical consideration in understanding their effects. Because endocrine systems exhibit tissue-, cell-, and receptor-specific actions during the life cycle, EDC can produce complex, mosaic effects. This complexity causes difficulty when a static approach to toxicity through endocrine mechanisms driven by rigid guidelines is used to identify EDC and manage risk to human and wildlife populations. We propose that principles taken from fundamental endocrinology be employed to identify EDC and manage their risk to exposed populations. We emphasize the importance of developmental stage and, in particular, the realization that exposure to a presumptive "safe" dose of chemical may impact a life stage when there is normally no endogenous hormone exposure, thereby underscoring the potential for very low-dose EDC exposures to have potent and irreversible effects. Finally, with regard to the current program designed to detect putative EDC, namely, the Endocrine Disruptor Screening Program, we offer recommendations for strengthening this program through the incorporation of basic endocrine principles to promote further understanding of complex EDC effects, especially due to developmental exposures.

Indexed as

Societies, MedicalEndocrine DisruptorsHumansPublic HealthEndocrine Disruptors

Identifiers

PMID22733974
PMCPMC3423612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.