ArticleProceedings of the National Academy of Sciences of the United States of America2012
Intestinal synthesis and secretion of bile salts as an adaptation to developmental biliary atresia in the sea lamprey.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Behavioral, Endocrine, and Neuronal Responses to Odors in Lampreys.Animals : an open access journal from MDPI · 2025Review
- Liver metabolomic profiles of sea lamprey (Petromyzon marinus) are influenced by sex and maturation stages.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Comparative study on a unique architecture of the brook lamprey liver and that of the hagfish and banded houndshark liver.Cell and tissue research · 2024Article
- Histomorphological and Dynamical Changes in Female River Lampreys during Maturation under Controlled Conditions as a Part of Lamprey Restoration Programs.Animals : an open access journal from MDPI · 2024Article
- Evolutionary analysis of SLC10 family members and insights into function and expression regulation of lamprey NTCP.Fish physiology and biochemistry · 2024Article
- Male lake char release taurocholic acid as part of a mating pheromone.The Journal of experimental biology · 2024Article
- The metabolic adaptation of bile acids and cholesterol after biliary atresia in lamprey via transcriptome-based analysis.Heliyon · 2023Article
- Biliary Atresia Animal Models: Is the Needle in a Haystack?International journal of molecular sciences · 2022Review
- Bile acid production is life-stage and sex-dependent and affected by primer pheromones in the sea lamprey.The Journal of experimental biology · 2021Article
- Hsp90 and hepatobiliary transformation during sea lamprey metamorphosis.BMC developmental biology · 2015Article
- Intestinal transport and metabolism of bile acids.Journal of lipid research · 2015Review
- The Sea Lamprey as an Etiological Model for Biliary Atresia.BioMed research international · 2015Review
- Chemical cues and pheromones in the sea lamprey (Petromyzon marinus).Frontiers in zoology · 2015Review
- A new clarification method to visualize biliary degeneration during liver metamorphosis in Sea Lamprey (Petromyzon marinus).Journal of visualized experiments : JoVE · 2014Article
- Metabolic consequences of microRNA-122 inhibition in rainbow trout, Oncorhynchus mykiss.BMC genomics · 2014Article
- Biosynthesis and release of pheromonal bile salts in mature male sea lamprey.BMC biochemistry · 2013Article
- Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion.Hepatology (Baltimore, Md.) · 2013Article
- Long-Term Survival of Biliary Atresia without any Surgery: Lessons Learnt from Lamprey.Journal of neonatal surgeryArticle
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Bile salt synthesis is a specialized liver function in vertebrates. Bile salts play diverse roles in digestion and signaling, and their homeostasis is maintained by controlling input (biosynthesis) and intestinal conservation. Patients with biliary atresia (i.e., obliteration of the biliary tree) suffer liver fibrosis and cirrhosis. In contrast, sea lamprey thrives despite developmental biliary atresia. We discovered that the sea lamprey adapts to biliary atresia through a unique mechanism of de novo synthesis and secretion of bile salts in intestine after developmental biliary atresia, in addition to known mechanisms, such as the reduction of bile salt synthesis in liver. During and after developmental biliary atresia, expression of cyp7a1 in intestine increased by more than 100-fold (P < 0.001), whereas in liver it decreased by the same magnitude (P < 0.001). Concurrently, bile salt pools changed in similar patterns and magnitudes in these two organs and the composition shifted from C24 bile alcohol sulfates to taurine-conjugated C24 bile acids. In addition, both in vivo and ex vivo experiments showed that aductular sea lamprey secreted taurocholic acid into its intestinal lumen. Our results indicate that the sea lamprey, a jawless vertebrate, may be in an evolutionarily transitional state where bile salt synthesis occurs in both liver and intestine. Understanding the molecular basis of these mechanisms may shed light on the evolution of bile salt synthesis and possible therapy for infant biliary atresia.
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Registered trials
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