ArticleProceedings of the National Academy of Sciences of the United States of America2012
Gonads directly regulate growth in teleosts.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 77 citations in OpenAlex.
- Identification of the Potential Functions of theInternational journal of molecular sciences · 2026Article
- The Involvement of Melatonin in the Dimorphism of Glucose and Lipid Metabolism of Tilapia.Biomolecules · 2025Article
- Plasticity in medaka gonadotropes via cell proliferation and phenotypic conversion.The Journal of endocrinology · 2020Article
- Identification and Characterization of a Non-muscular Myostatin in the Nile Tilapia.Frontiers in endocrinology · 2020Article
- High-Density Linkage Map and QTLs for Growth in Snapper (G3 (Bethesda, Md.) · 2019Article
- Deciphering Direct and Indirect Effects of Neurokinin B and GnRH in the Brain-Pituitary Axis of Tilapia.Frontiers in endocrinology · 2019Article
- Sex steroid production associated with puberty is absent in germ cell-free salmon.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In general, there is a relationship between growth and reproduction, and gonads are known to be important organs for growth, but direct evidence for their role is lacking. Here, using a fish model, we report direct evidence that gonads are endocrine organs equal to the pituitary in controlling body growth. Gonadal loss of function, gain of function, and rescue of growth were investigated in tilapia. Gonadectomy experiments were carried out in juvenile males and females. Gonadectomy significantly retarded growth compared with controls; however, this retardation was rescued by the implantation of extirpated gonads. Because gonads express growth hormone, it is possible that gonads control body growth through the secretion of growth hormone and/or other endocrine factors. We propose that gonads are integral players in the dynamic regulation of growth in teleosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.