ArticleThe Journal of physiology2012
Sub- and suprathreshold adaptation currents have opposite effects on frequency tuning.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Interleaved single and bursting spiking resonance in neurons.PLoS computational biology · 2025Article
- Interspike interval correlations in neuron models with adaptation and correlated noise.PLoS computational biology · 2021Article
- Activation of GABAJournal of neurophysiology · 2020Article
- Article
- SK channel subtypes enable parallel optimized coding of behaviorally relevant stimulus attributes: A review.Channels (Austin, Tex.) · 2017Review
- Optimized Parallel Coding of Second-Order Stimulus Features by Heterogeneous Neural Populations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Impact of slow K(+) currents on spike generation can be described by an adaptive threshold model.Journal of computational neuroscience · 2016Article
- Temporal decorrelation by SK channels enables efficient neural coding and perception of natural stimuli.Nature communications · 2016Article
- Burst Firing in the Electrosensory System of Gymnotiform Weakly Electric Fish: Mechanisms and Functional Roles.Frontiers in computational neuroscience · 2016Review
- Impact of sub and supra-threshold adaptation currents in networks of spiking neurons.Journal of computational neuroscience · 2015Article
- Serotonin modulates electrosensory processing and behavior via 5-HT2-like receptors.Neuroscience · 2014Article
- Motion processing across multiple topographic maps in the electrosensory system.Physiological reports · 2014Article
- Neuromodulation of early electrosensory processing in gymnotiform weakly electric fish.The Journal of experimental biology · 2013Review
- Patterns of interval correlations in neural oscillators with adaptation.Frontiers in computational neuroscience · 2013Article
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Authors and funding
3 authors.
Funding
Abstract
Natural stimuli are often characterized by statistics that can vary over orders of magnitude. Experiments have shown that sensory neurons continuously adapt their responses to changes in these statistics, thereby optimizing information transmission. However, such adaptation can also alter the neuronal transfer function by attenuating if not eliminating responses to the low frequency components of time varying stimuli,which can create ambiguity in the neural code. We recorded from electrosensory pyramidal neurons before and after pharmacological inactivation of either calcium-activated (I(AHP)) or KCNQ voltage-gated potassium currents (I(M)). We found that blocking each current decreased adaptation in a similar fashion but led to opposite changes in the neuronal transfer function. Indeed, blocking I(AHP) increased while blocking I(M) instead decreased the response to low temporal frequencies. To understand this surprising result, we built a mathematical model incorporating each channel type. This model predicted that these differential effects could be accounted for by differential activation properties. Our results show that the mechanisms that mediate adaptation can either increase or decrease the response to low frequency stimuli. As such, they suggest that the nervous system resolves ambiguity resulting from adaptation through independent control of adaptation and the neuronal transfer function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.