ArticleThe Journal of physiology2012
Pulmonary vascular distensibility predicts aerobic capacity in healthy individuals.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 98 citations in OpenAlex.
- Effects of Endurance Training Intensity on Pulmonary Diffusing Capacity at Rest and after Maximal Aerobic Exercise in Young Athletes.International journal of environmental research and public health · 2021Trial
- Pulmonary Vascular Distensibility Predicts Pulmonary Hypertension Severity, Exercise Capacity, and Survival in Heart Failure.Circulation. Heart failure · 2016Trial
- Hypoxia and exercise increase the transpulmonary passage of 99mTc-labeled albumin particles in humans.PloS one · 2014Trial
- The influence of metaboreflex activation on pulmonary pressure with combined chemoreflex activation in acute and chronic hypoxia.The Journal of physiology · 2026Article
- How Do Sex and Cardiorespiratory Fitness Impact Pulmonary Diffusing Capacity?Medicine and science in sports and exercise · 2025Article
- Relationship of Pulmonary Vascular Structure and Function With Exercise Capacity in Health and COPD.Chest · 2025Article
- Vasoreactivity and inhaled treprostinil response in interstitial lung disease pulmonary hypertension.ERJ open research · 2024Article
- Hypoxic pulmonary vasoconstriction does not limit maximal exercise capacity in healthy volunteers breathing 12% oxygen at sea level.Physiological reports · 2024Article
- The Pulmonary Vasculature.Seminars in respiratory and critical care medicine · 2023Review
- Pressure Overload and Right Ventricular Failure: From Pathophysiology to Treatment.Journal of clinical medicine · 2023Review
- Inhaled nitric oxide does not improve maximal oxygen consumption in endurance trained and untrained healthy individuals.European journal of applied physiology · 2022Article
- Nedocromil sodium and diphenhydramine HCl ameliorate exercise-induced arterial hypoxemia in highly trained athletes.Physiological reports · 2022Article
- Pulmonary vascular distensibility with passive leg raise is comparable to exercise and predictive of clinical outcomes in pulmonary hypertension.Pulmonary circulation · 2022Article
- Right ventricular-pulmonary arterial coupling impairment and exercise capacity in obese adults.Frontiers in cardiovascular medicine · 2022Article
- Simultaneous Measurement of Lung Diffusing Capacity and Pulmonary Hemodynamics Reveals Exertional Alveolar-Capillary Dysfunction in Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2021Observational
- Exercise intolerance in pulmonary arterial hypertension: insight into central and peripheral pathophysiological mechanisms.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Pulmonary vascular dysfunction among people aged over 65 years in the community in the Atherosclerosis Risk In Communities (ARIC) Study: A cross-sectional analysis.PLoS medicine · 2020Article
- Prognostic value of right pulmonary artery distensibility in dogs with pulmonary hypertension.Journal of veterinary science · 2019Article
- Respiratory Determinants of Exercise Limitation: Focus on Phrenic Afferents and the Lung Vasculature.Clinics in chest medicine · 2019Review
- Pulmonary Limitations in Heart Failure.Clinics in chest medicine · 2019Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been suggested that shallow slopes of mean pulmonary artery pressure (MPPA)–cardiac output (Q) relationships and pulmonary transit of agitated contrast during exercise may be associated with a higher maximal aerobic capacity V(O(2)max). If so, individuals with a higher V(O(2)max) could also exhibit a higher pulmonary vascular distensibility and increased pulmonary capillary blood volume during exercise. Exercise stress echocardiography was performed with repetitive injections of agitated contrast and measurements of MPPA, Q and lung diffusing capacities for carbon monoxide (D(L,CO)) and nitric oxide (D(L,CO)) in 24 healthy individuals. A pulmonary vascular distensibility coefficient α was mathematically determined from the slight natural curvilinearity of multipoint MPPA–Q plots. Membrane (D(m)) and capillary blood volume (V(c)) components of lung diffusing capacity were calculated. Maximal exercise increased MPPA, cardiac index (CI), D(L,CO) and (D(L,NO). The slope of the linear best fit of MPPA–CI was 3.2 ± 0.5 mmHg min l(-1) m(2) and α was 1.1 ± 0.3% mmHg(-1). A multivariable analysis showed that higher α and greater V(c) independently predicted V(O(2)max). All individuals had markedly positive pulmonary transit of agitated contrast at maximal exercise, with increases proportional to increases in pulmonary capillary pressure and V(c). Pulmonary transit of agitated contrast was not related to pulse oximetry arterial oxygen saturation. Therefore, a more distensible pulmonary circulation and a greater pulmonary capillary blood volume are associated with a higher V(O(2)max) in healthy individuals. Agitated contrast commonly transits through the pulmonary circulation at exercise, in proportion to increased pulmonary capillary pressures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.