ReviewThe Journal of physiology2012
Contribution of intravascular versus interstitial purines and nitric oxide in the regulation of exercise hyperaemia in humans.
Review in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Contribution of Adenosine in the Physiological Changes and Injuries Secondary to Exposure to Extreme Oxygen Pressure in Healthy Subjects.Biomedicines · 2022Review
- Review
- Hyperoxia During Exercise: Impact on Adenosine Plasma Levels and Hemodynamic Data.Frontiers in physiology · 2020Article
- Ablation of both Cx40 and Panx1 results in similar cardiovascular phenotypes exhibited in Cx40 knockout mice.Bioscience reports · 2019Article
- The role of perfusion in the oxygen extraction capability of skin and skeletal muscle.American journal of physiology. Heart and circulatory physiology · 2016Article
- Nitrate as a source of nitrite and nitric oxide during exercise hyperemia in rat skeletal muscle.Nitric oxide : biology and chemistry · 2016Article
- Article
- Red cell physiology and signaling relevant to the critical care setting.Current opinion in pediatrics · 2015Review
- The effect of purinergic P2 receptor blockade on skeletal muscle exercise hyperemia in miniature swine.European journal of applied physiology · 2014Article
- Pre-exposure to adenosine, acting via A(2A) receptors on endothelial cells, alters the protein kinase A dependence of adenosine-induced dilation in skeletal muscle resistance arterioles.The Journal of physiology · 2014Article
- Kinetics of extracellular ATP in mastoparan 7-activated human erythrocytes.Biochimica et biophysica acta · 2013Article
- Effect of extraluminal ATP application on vascular tone and blood flow in skeletal muscle: implications for exercise hyperemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Contribution of non-endothelium-dependent substances to exercise hyperaemia: are they O(2) dependent?The Journal of physiology · 2012Review
- Vasodilator interactions in skeletal muscle blood flow regulation.The Journal of physiology · 2012Review
- Inefficient functional sympatholysis is an overlooked cause of malperfusion in contracting skeletal muscle.The Journal of physiology · 2012Review
- In search of a vasodilator: is ATP the answer?The Journal of physiology · 2012Article
- A novel role for the red blood cell in the regulation of tissue O₂ supply.The Journal of physiology · 2012Article
- ATP as a mediator of erythrocyte-dependent regulation of skeletal muscle blood flow and oxygen delivery in humans.The Journal of physiology · 2012Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regulation of blood flow to skeletal muscle involves a complex interaction between several locally formed vasodilators that are produced both in the skeletal muscle interstitium and intravascularly. The gas nitric oxide (NO) and the purines ATP and adenosine, are potent vasodilators that are formed by multiple cell types and released into the skeletal muscle interstitium and in plasma in response to muscle contraction. Cellular sources of ATP and NO in plasma are erythrocytes and endothelial cells, whereas interstitial sources are skeletal muscle cells and endothelial cells. Adenosine originates primarily from extracellular degradation of ATP. During exercise the concentrations of ATP and adenosine increase markedly in the interstitium with smaller increases occurring in plasma, and thus the interstitial concentration during exercise is severalfold higher than in plasma. The concentration of NO metabolites (NOx) in interstitium and plasma does not change during exercise and is similar in the two compartments. Adenosine and NO have been shown to contribute to exercise hyperaemia whereas the role of ATP remains unclear due to lack of specific purinergic receptor blockers. The relative role of intravascular versus interstitial vasodilators is not known but evidence suggests that both compartments are important. In cardiovascular disease, a reduced capacity to form adenosine in the muscle interstitium may be a contributing factor in increased peripheral vascular resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.