ArticleInfection and immunity2012
Host response signature to Staphylococcus aureus alpha-hemolysin implicates pulmonary Th17 response.
Article in Infection and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Daphnoretin as a potent sortase A inhibitor effectively disarms drug-resistant Staphylococcus aureus infections.World journal of microbiology & biotechnology · 2026Article
- Machine Learning with Alpha Toxin Phenotype to Predict Clinical Outcome in Patients withToxins · 2023Article
- Gut-Lung Microbiota Interaction in COPD Patients: A Literature Review.Medicina (Kaunas, Lithuania) · 2022Review
- IL-33-mediated Eosinophilia Protects against Acute Lung Injury.American journal of respiratory cell and molecular biology · 2021Article
- Article
- Co-infection ofFrontiers in cellular and infection microbiology · 2020Article
- Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.Cell host & microbe · 2019Article
- Messing with the Sentinels-The Interaction ofMicroorganisms · 2018Review
- Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence.Cell host & microbe · 2018Article
- Article
- Pathogenesis of Staphylococcus aureus Bloodstream Infections.Annual review of pathology · 2016Review
- Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells.The Journal of clinical investigation · 2016Article
- Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia.Infection and immunity · 2015Article
- Macrophage-expressed perforins mpeg1 and mpeg1.2 have an anti-bacterial function in zebrafish.Journal of innate immunity · 2015Article
- Article
- Mouse models for infectious diseases caused by Staphylococcus aureus.Journal of immunological methods · 2014Review
- Where does a Staphylococcus aureus vaccine stand?Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2014Review
- Staphylococcal bicomponent pore-forming toxins: targets for prophylaxis and immunotherapy.Toxins · 2014Review
- TGFBR1 is required for mouse myometrial development.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Tissue-specific patterning of host innate immune responses by Staphylococcus aureus α-toxin.Journal of innate immunity · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Staphylococcus aureus pneumonia causes significant morbidity and mortality. Alpha-hemolysin (Hla), a pore-forming cytotoxin of S. aureus, has been identified through animal models of pneumonia as a critical virulence factor that induces lung injury. In spite of considerable molecular knowledge of how this cytotoxin injures the host, the precise host response to Hla in the context of infection remains poorly understood. We employed whole-genome expression profiling of infected lungs to define the host response to wild-type S. aureus compared with the response to an Hla-deficient isogenic mutant in experimental pneumonia. These data provide a complete expression profile at 4 and at 24 h postinfection, revealing a unique response to the toxin-expressing strain. Gene ontogeny analysis revealed significant differences in the extracellular matrix and cardiomyopathy pathways, both of which govern cellular interactions in the tissue microenvironment. Evaluation of individual transcript responses to Hla-secreting staphylococci was notable for upregulation of host cytokine and chemokine genes, including the p19 subunit of interleukin-23. Consistent with this observation, the cellular immune response to infection was characterized by a prominent Th17 response to the wild-type pathogen. These findings define specific host mRNA responses to Hla-producing S. aureus, coupling the pulmonary Th17 response to the secretion of this cytotoxin. Expression profiling to define the host response to a single virulence factor proved to be a valuable tool in identifying pathways for further investigation in S. aureus pneumonia. This approach may be broadly applicable to the study of bacterial toxins, defining host pathways that can be targeted to mitigate toxin-induced disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.