Evidence map›Paper›PMID 22733402›Full record

ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2012

Centromeric heterochromatin assembly in fission yeast--balancing transcription, RNA interference and chromatin modification.

Benjamin J Alper, Brandon R Lowe, Janet F Partridge

Abstract readReview
In one paragraph

Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
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  10. RNA matchmaking in chromatin regulation.Biochemical Society transactions · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Benjamin J AlperDepartment of Biochemistry, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Brandon R Lowe
Janet F Partridge

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Establishment of HeterochromatinR01GM084045 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PARTRIDGE, JANET F · 2008 to 2012
$1.8M
NCI NIH HHS 2 P30 CA 21765NCI NIH HHS P30 CA021765NIGMS NIH HHS R01 GM084045NIGMS NIH HHS R01-GM084045
6 · The paper itself

Abstract

Distinct regions of the eukaryotic genome are packaged into different types of chromatin, with euchromatin representing gene rich, transcriptionally active regions and heterochromatin more condensed and gene poor. The assembly and maintenance of heterochromatin is important for many aspects of genome control, including silencing of gene transcription, suppression of recombination, and to ensure proper chromosome segregation. The precise mechanisms underlying heterochromatin establishment and maintenance are still unclear, but much progress has been made towards understanding this process during the last few years, particularly from studies performed in fission yeast. In this review, we hope to provide a conceptual model of centromeric heterochromatin in fission yeast that integrates our current understanding of the competing forces of transcription, replication, and RNA decay that influence its assembly and propagation.

Indexed as

Chromatin Assembly and DisassemblyRNA InterferenceTranscription, GeneticAnimalsCell Cycle ProteinsCentromereDNA ReplicationEpigenesis, GeneticHeterochromatinHistonesMammalsMethylationMultiprotein ComplexesRNA StabilitySchizosaccharomycesCell Cycle ProteinsHeterochromatinHistonesMultiprotein Complexes

Identifiers

PMID22733402
PMCPMC3580186

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.