Evidence map›Paper›PMID 22733069›Full record

ArticleAntimicrobial agents and chemotherapy2012

Molecular organization of small plasmids bearing blaTEM-1 and conferring resistance to β-lactams in Haemophilus influenzae.

Annette Søndergaard, Alvaro San Millan, Alfonso Santos-Lopez, Signe M Nielsen, Bruno Gonzalez-Zorn, Niels Nørskov-Lauritsen

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Progression of antibiotic resistance inClinical microbiology reviews · 2025
    Review
  4. Haemophilus influenzae one day in Denmark: prevalence, circulating clones, and dismal resistance to aminopenicillins.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Annette SøndergaardDepartment of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark.
Alvaro San Millan
Alfonso Santos-Lopez
Signe M Nielsen
Bruno Gonzalez-Zorn
Niels Nørskov-Lauritsen
Aarhus University Hospital · DKUniversidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TEM-1 is the dominant β-lactamase of Haemophilus influenzae and can be located on small plasmids. Three distinct plasmids with sizes from 4,304 to 5,646 nucleotides (nt) were characterized: pA1606, pA1209, and pPN223. In addition to TEM-1 and a replication enzyme of the Rep 3 superfamily, pA1606 carries a Tn3 resolvase gene and pA1606 and pA1209 carry an open reading frame (ORF) similar to a plasmid recombination enzyme gene described in Gram-positive bacteria. The plasmids transformed strain Rd to the ampicillin-resistant phenotype.

Indexed as

PlasmidsAmpicillinBase Sequencebeta-Lactamasesbeta-Lactam Resistancebeta-LactamsHaemophilus influenzaeMicrobial Sensitivity TestsMolecular Sequence DataOpen Reading FramesRecombinasesRNA-Dependent RNA PolymeraseTransformation, BacterialTransposon ResolvasesAmpicillinbeta-Lactamasesbeta-lactamase TEM-1beta-LactamsRecombinasesRNA-Dependent RNA PolymeraseTn3 resolvaseTransposon Resolvases

Identifiers

PMID22733069
PMCPMC3421876
OpenAlexW2103376311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.